狒狒对乙型肝炎病毒感染不敏感。
Lack of susceptibility of baboons to infection with hepatitis B virus.
作者信息
Michaels M G, Lanford R, Demetris A J, Chavez D, Brasky K, Fung J, Starzl T E
机构信息
Department of Pediatrics, University of Pittsburgh, School of Medicine, Pennsylvania, USA.
出版信息
Transplantation. 1996 Feb 15;61(3):350-1. doi: 10.1097/00007890-199602150-00002.
Historically, hepatitis B virus (HBV) has been considered species specific and unable to infect baboons. Based on this premise, two patients with HBV endstage liver disease underwent baboon liver xenotransplantation. To study whether baboons are susceptible to HBV infection, four baboons (two receiving immunosuppressive therapy) were inoculated with HBV. Animals were followed for 6 months: clinical examinations and biochemical studies were normal, hepatitis B surface antigen and hepatitis B core antigen staining of biopsies was negative, and HBV serology remained negative. HBV polymerase chain reaction was transiently positive in one animal, which most likely reflects the initial inoculation. This pilot study corroborates historical evidence and beliefs that baboons are resistant to HBV.
从历史上看，乙型肝炎病毒（HBV）一直被认为具有种属特异性，无法感染狒狒。基于这一前提，两名患有HBV终末期肝病的患者接受了狒狒肝脏异种移植。为了研究狒狒是否易受HBV感染，对四只狒狒（两只接受免疫抑制治疗）接种了HBV。对动物进行了6个月的跟踪观察：临床检查和生化研究均正常，活检组织的乙肝表面抗原和乙肝核心抗原染色均为阴性，HBV血清学检查仍为阴性。一只动物的HBV聚合酶链反应呈短暂阳性，这很可能反映了最初的接种情况。这项初步研究证实了狒狒对HBV具有抗性的历史证据和观点。
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