Clark T J, Hetzel M R
Br J Dis Chest. 1977 Apr;71(2):87-92. doi: 10.1016/0007-0971(77)90087-0.
We have studied possible aetiological factors in the large diurnal variation in peak expiratory flow rate seen in some asthmatics. This phenomenon occurred in both atopic and non-atopic patients. It could not be attributed to recumbency in bed at night or to allergy to the house dust mite in bedding. Circadian variation in asthmatic shift workers was intimately related to sleep and virtually independent of solar time. Treatment tends to lose its effect as it is discontinued during sleep and this increases the apparent diurnal variation in many patients. Excessive circadian variation may be an important factor in sudden asthma deaths. The importance of effective nocturnal medication is stressed.
我们研究了部分哮喘患者呼气峰值流速出现大幅昼夜变化的可能病因。这种现象在特应性和非特应性患者中均有发生。它不能归因于夜间卧床或对床上尘螨过敏。哮喘轮班工作者的昼夜变化与睡眠密切相关，且几乎与太阳时间无关。治疗在睡眠期间中断时往往会失去效果，这增加了许多患者明显的昼夜变化。昼夜变化过大可能是哮喘猝死的一个重要因素。强调了夜间有效用药的重要性。
