Márquez J A, Serrano R
Instituto de Biologia Molecular y Celular de Plantas, Valencia, Spain.
FEBS Lett. 1996 Mar 11;382(1-2):89-92. doi: 10.1016/0014-5793(96)00157-3.
The yeast PMR2/ENA1 gene encodes an ATPase involved in sodium extrusion and induced by NaCl. At low salt concentrations (0.3 M) induction is mediated by the HOG-MAP kinase pathway, a system activated by non-specific osmotic stress. At high salt concentrations (0.8 M) induction is mediated by the protein phosphatase calcineurin and is specific for sodium. Protein kinase A and Sis2p/Hal3p modulate PMR2/ENA1 expression as negative and positive factors, respectively but Sis2p/Hal3p does not participate in the transduction of the salt signal. Salt stress decreases the level of cAMP and the resulting decrease in protein kinase A activity may contribute to HOG-mediated induction.
酵母PMR2/ENA1基因编码一种参与钠排出且受NaCl诱导的ATP酶。在低盐浓度（0.3M）下，诱导由HOG-MAP激酶途径介导，该途径是一个由非特异性渗透胁迫激活的系统。在高盐浓度（0.8M）下，诱导由蛋白磷酸酶钙调神经磷酸酶介导且对钠具有特异性。蛋白激酶A和Sis2p/Hal3p分别作为负性和正性因子调节PMR2/ENA1的表达，但Sis2p/Hal3p不参与盐信号的转导。盐胁迫降低了cAMP水平，蛋白激酶A活性的相应降低可能有助于HOG介导的诱导。
