Vandermolen D T, Borzelleca J F
Department of Obstetrics and Gynecology, Medical College of Virginia, Richmond 23298-0034, USA.
Fertil Steril. 1996 May;65(5):916-21.
To evaluate the discriminatory ability of maternal serum creatine kinase (SCK) as a test for ectopic pregnancy (EP).
Serum creatine kinase concentrations were obtained prospectively from symptomatic patients being evaluated for early abnormal pregnancy. Serum creatine kinase concentrations from all patients and from a subset of these patients with maternal serum beta-hCG concentrations < 6,500 mIU/mL (conversion factor to SI unit, 1.00) were analyzed with descriptive statistics, receiver operator characteristic (ROC) curve analysis, and calculations of predictive values.
A university hospital emergency room.
Fifty-six patients with intrauterine gestations (25 with beta-hCG concentrations < 6,500 mIU/mL) and 23 patients with EP (20 with beta-hCG concentrations < 6,500 mIU/mL) were studied.
For all patients and the subgroup with beta-hCG concentrations < 6,500 mIU/mL, mean SCK levels were not significantly different between ectopic and intrauterine gestations. For all patients and the subgroup with beta-hCG concentrations < 6,500 mIU/mL, the areas under the ROC curves did not demonstrate discriminatory ability of the SCK test. The highest positive predictive value of an elevated SCK for EP was 52% using the SCK concentration of 70 U/L, and this was seen in the subgroup of patients with beta-hCG values < 6,500 mIU/mL.
Maternal SCK concentrations do not reliably predict EP.
评估母体血清肌酸激酶（SCK）作为异位妊娠（EP）检测指标的鉴别能力。
前瞻性地获取有早期异常妊娠症状的患者的血清肌酸激酶浓度。对所有患者以及其中母体血清β-hCG浓度<6500 mIU/mL（换算系数至国际单位制，1.00）的患者亚组的血清肌酸激酶浓度进行描述性统计分析、受试者操作特征（ROC）曲线分析以及预测值计算。
一所大学医院急诊室。
研究了56例宫内妊娠患者（25例β-hCG浓度<6500 mIU/mL）和23例EP患者（20例β-hCG浓度<6500 mIU/mL）。
对于所有患者以及β-hCG浓度<6500 mIU/mL的亚组，异位妊娠和宫内妊娠之间的平均SCK水平无显著差异。对于所有患者以及β-hCG浓度<6500 mIU/mL的亚组，ROC曲线下面积未显示出SCK检测的鉴别能力。使用70 U/L的SCK浓度时，SCK升高对EP的最高阳性预测值为52%，这在β-hCG值<6500 mIU/mL的患者亚组中可见。
母体SCK浓度不能可靠地预测EP。
