头孢西丁：一项医院研究。
Cefoxitin: a hospital study.
作者信息
Geddes A M, Schnurr L P, Ball A P, McGhie D, Brookes G R, Wise R, Andrews J
出版信息
Br Med J. 1977 Apr 30;1(6069):1126-8. doi: 10.1136/bmj.1.6069.1126.
Abstract
Cefoxitin is a new cephamycin antibiotic that has recently become available for clinical trial. We report here the results of an uncontrolled trial of cefoxitin treatment in 31 hospital patients with various acute infections, 20 of whom were cured. Serum, urine, and bile concentrations of cefoxitin greatly exceeded the minimum inhibitory concentration (MIC) required for clinically important Gram-negative organisms. We conclude that cefoxitin will have a place in the management of serious infections, particularly in the abdominal cavity and renal tracts.
摘要
头孢西丁是一种新型头孢霉素抗生素，最近已可用于临床试验。我们在此报告对31例患有各种急性感染的住院患者进行头孢西丁治疗的非对照试验结果，其中20例治愈。头孢西丁的血清、尿液和胆汁浓度大大超过了临床上重要的革兰氏阴性菌所需的最低抑菌浓度（MIC）。我们得出结论，头孢西丁在严重感染的治疗中，特别是在腹腔和泌尿道感染的治疗中将会占有一席之地。
相似文献
1
Cefoxitin: a hospital study.头孢西丁：一项医院研究。
Br Med J. 1977 Apr 30;1(6069):1126-8. doi: 10.1136/bmj.1.6069.1126.
2
Clinical use of cefoxitin, a new semisynthetic cephamycin.
N Z Med J. 1978 Jul 26;88(616):46-9.
3
Results of a clinical trial of cefoxitin, a new cephamycin antibiotic.新型头孢霉素抗生素头孢西丁的一项临床试验结果。
Antimicrob Agents Chemother. 1977 Nov;12(5):636-41. doi: 10.1128/AAC.12.5.636.
4
Cefoxitin: clinical evaluation in thirty-eight patients.头孢西丁：38例患者的临床评估
Antimicrob Agents Chemother. 1977 Mar;11(3):427-34. doi: 10.1128/AAC.11.3.427.
5
Studies with cefuroxime and cefoxitin.头孢呋辛和头孢西丁的研究。
Scand J Infect Dis Suppl. 1978(13):78-81.
6
Cefoxitin: single-agent treatment of mixed aerobic-anaerobic pelvic infections.
Obstet Gynecol. 1979 Aug;54(2):193-8.
7
Use of cefoxitin, new cephalosporin-like antibiotic, in the treatment of aerobic and anaerobic infections.新型头孢菌素类抗生素头孢西丁在需氧菌和厌氧菌感染治疗中的应用。
Antimicrob Agents Chemother. 1978 Dec;14(6):866-75. doi: 10.1128/AAC.14.6.866.
8
Cefoxitin sodium and cephalothin in the treatment of serious infections.
J Antimicrob Chemother. 1978 Jul;4(B):105-11. doi: 10.1093/jac/4.suppl_b.105.
9
[Clinical experience with cefoxitin in the field of internal medicine (author's transl)].头孢西丁在内科领域的临床经验（作者译）
Jpn J Antibiot. 1978 Jul;31(7):353-8.
10
Use of cefoxitin sodium in moderate to severe surgical infections.头孢西丁钠在中重度外科感染中的应用。
J Antimicrob Chemother. 1978 Jul;4(B):231-3. doi: 10.1093/jac/4.suppl_b.231.
引用本文的文献
1
Microbiological Air Quality and Drug Resistance in Airborne Bacteria Isolated from a Waste Sorting Plant Located in Poland-A Case Study.波兰一家垃圾分类厂分离出的空气传播细菌的微生物空气质量和耐药性——案例研究
Microorganisms. 2020 Jan 31;8(2):202. doi: 10.3390/microorganisms8020202.
2
Anti-anaerobic antimicrobial agents: cefoxitin, cefotetan, clindamycin, and metronidazole.抗厌氧抗菌药物：头孢西丁、头孢替坦、克林霉素和甲硝唑。
Tex Heart Inst J. 1990;17(2):77-85.
3
Antibiotic trials in intra-abdominal infections. A critical evaluation of study design and outcome reporting.腹腔内感染的抗生素试验。对研究设计和结果报告的批判性评价。
Ann Surg. 1984 Jul;200(1):29-39. doi: 10.1097/00000658-198407000-00005.
4
Clinical trial of cefonicid for treatment of skin infections.头孢尼西治疗皮肤感染的临床试验。
Antimicrob Agents Chemother. 1983 Jun;23(6):944-6. doi: 10.1128/AAC.23.6.944.
5
Pharmacokinetics of cefoxitin in patients with normal or impaired renal function.头孢西丁在肾功能正常或受损患者中的药代动力学。
Eur J Clin Pharmacol. 1979 Sep;16(2):119-24. doi: 10.1007/BF00563118.
6
Cefoxitin: a review of its antibacterial activity, pharmacological properties and therapeutic use.头孢西丁：抗菌活性、药理特性及治疗用途综述
Drugs. 1979 Jan;17(1):1-37. doi: 10.2165/00003495-197917010-00001.
本文引用的文献
1
Susceptibility of clinical isolates of bacteria to cefoxitin and cephalothin.临床分离细菌对头孢西丁和头孢噻吩的敏感性。
Antimicrob Agents Chemother. 1974 Sep;6(3):320-3. doi: 10.1128/AAC.6.3.320.
2
Cefoxitin, a semisynthetic cephamycin antibiotic: antibacterial spectrum and resistance to hydrolysis by gram-negative beta-lactamases.头孢西丁，一种半合成头孢霉素抗生素：抗菌谱及对革兰氏阴性β-内酰胺酶水解的抗性。
Antimicrob Agents Chemother. 1974 Aug;6(2):170-6. doi: 10.1128/AAC.6.2.170.
3
Semisynthetic cephalosporins via a novel acyl exchange reaction.
J Am Chem Soc. 1972 Feb 23;94(4):1410-1. doi: 10.1021/ja00759a090.
4
Cefoxitin, a semisynthetic cephamycin antibiotic: in vivo evaluation.头孢西丁，一种半合成头孢霉素类抗生素：体内评价
Antimicrob Agents Chemother. 1974 Jan;5(1):33-7. doi: 10.1128/AAC.5.1.33.
5
Cefoxitin, a new semi-synthetic cephamycin: an in-vitro and in-vivo comparison with cephalothin.头孢西丁，一种新型半合成头孢霉素：与头孢噻吩的体外及体内比较
Br Med J. 1973 Dec 15;4(5893):653-5. doi: 10.1136/bmj.4.5893.653.
6
Cefuroxime, a new cephalosporin antibiotic: activity in vitro.头孢呋辛，一种新型头孢菌素抗生素：体外活性
Antimicrob Agents Chemother. 1976 Mar;9(3):511-9. doi: 10.1128/AAC.9.3.511.
7
Comparative study of the in vitro antibacterial activity of cefoxitin, cefuroxine, and cephaloridine.头孢西丁、头孢呋辛和头孢噻啶体外抗菌活性的比较研究。
Antimicrob Agents Chemother. 1976 Mar;9(3):506-10. doi: 10.1128/AAC.9.3.506.
8
Cephamycins: a review, prospects and some original observations.头孢霉素：综述、前景及一些原创性观察
Infection. 1975;3(4):183-8. doi: 10.1007/BF01642764.
Zotero 插件