Halbreich U, Petty F, Yonkers K, Kramer G L, Rush A J, Bibi K W
Department of Psychiatry, State University of New York at Buffalo 14215, USA.
Am J Psychiatry. 1996 May;153(5):718-20. doi: 10.1176/ajp.153.5.718.
Plasma gamma-aminobutyric acid (GABA) levels have been reported to be low in some patients with major depressive disorder. Premenstrual dysphoric disorder is often associated with major depressive disorder. Therefore, the authors sought to determine whether women with premenstrual dysphoric disorder with or without prior major depressive disorder also had low plasma GABA levels.
Plasma GABA levels were measured in 27 women with premenstrual dysphoric disorder and 21 comparison women during the the mid-follicular and late luteal phases of the menstrual cycle.
In comparison women, plasma GABA levels increased from the mid-follicular to the late luteal phase. Women with premenstrual dysphoric disorder and a past history of major depressive disorder had low plasma GABA levels during both phases. In women with premenstrual dysphoric disorder but no past major depressive disorder, plasma GABA levels decreased from the nonsymptomatic, mid-follicular phase to the symptomatic, late luteal phase.
Decreased GABA function may represent a common biological link between subtypes of depressive and premenstrual dysphoric disorders. A trait in major depressive disorder and a state-dependent decrease in premenstrual dysphoric disorder might imply a possible continuum between the two disorders.
据报道，一些重度抑郁症患者的血浆γ-氨基丁酸（GABA）水平较低。经前烦躁障碍常与重度抑郁症相关。因此，作者试图确定患有或未患有既往重度抑郁症的经前烦躁障碍女性的血浆GABA水平是否也较低。
在月经周期的卵泡中期和黄体晚期，对27名经前烦躁障碍女性和21名对照女性的血浆GABA水平进行了测量。
在对照女性中，血浆GABA水平从卵泡中期到黄体晚期升高。有既往重度抑郁症病史的经前烦躁障碍女性在两个阶段的血浆GABA水平均较低。在无既往重度抑郁症病史的经前烦躁障碍女性中，血浆GABA水平从无症状的卵泡中期到有症状的黄体晚期降低。
GABA功能降低可能是抑郁和经前烦躁障碍亚型之间的共同生物学联系。重度抑郁症的一种特质以及经前烦躁障碍中与状态相关的降低可能意味着这两种障碍之间可能存在连续性。
