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Antimicrob Agents Chemother. 1995 Oct;39(10):2356-8. doi: 10.1128/AAC.39.10.2356.
2
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3
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引用本文的文献

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Effective Therapeutic Options for Melioidosis: Antibiotics versus Phage Therapy.类鼻疽的有效治疗选择：抗生素与噬菌体疗法
Pathogens. 2022 Dec 21;12(1):11. doi: 10.3390/pathogens12010011.
2
Human Melioidosis.类鼻疽病。
Clin Microbiol Rev. 2020 Mar 11;33(2). doi: 10.1128/CMR.00006-19. Print 2020 Mar 18.
3
Treatment and prophylaxis of melioidosis.类鼻疽的治疗与预防。
Int J Antimicrob Agents. 2014 Apr;43(4):310-8. doi: 10.1016/j.ijantimicag.2014.01.005. Epub 2014 Feb 3.
4
Clinical features and laboratory diagnosis of infection with the potential bioterrorism agents burkholderia mallei and burkholderia pseudomallei.潜在生物恐怖主义病原体鼻疽伯克霍尔德菌和类鼻疽伯克霍尔德菌感染的临床特征与实验室诊断
Int J Biomed Sci. 2007 Sep;3(3):144-52.
5
Melioidosis: a case report.类鼻疽：一例病例报告。
J Glob Infect Dis. 2011 Apr;3(2):183-6. doi: 10.4103/0974-777X.81697.
6
Melioidosis: epidemiology, pathophysiology, and management.类鼻疽病：流行病学、病理生理学及管理
Clin Microbiol Rev. 2005 Apr;18(2):383-416. doi: 10.1128/CMR.18.2.383-416.2005.
7
Modified virulence of antibiotic-induced Burkholderia pseudomallei filaments.抗生素诱导的类鼻疽伯克霍尔德菌丝状菌的毒力改变
Antimicrob Agents Chemother. 2005 Mar;49(3):1002-9. doi: 10.1128/AAC.49.3.1002-1009.2005.
8
Outcomes of patients with melioidosis treated with meropenem.用美罗培南治疗类鼻疽患者的结果。
Antimicrob Agents Chemother. 2004 May;48(5):1763-5. doi: 10.1128/AAC.48.5.1763-1765.2004.

本文引用的文献

1
Relapse in melioidosis: incidence and risk factors.类鼻疽病的复发：发病率及危险因素
J Infect Dis. 1993 Nov;168(5):1181-5.
2
Ceftazidime vs. amoxicillin/clavulanate in the treatment of severe melioidosis.头孢他啶与阿莫西林/克拉维酸治疗严重类鼻疽病的对比研究
Clin Infect Dis. 1994 Nov;19(5):846-53. doi: 10.1093/clinids/19.5.846.
3
Comparison of methodologies used in assessing the postantibiotic effect.评估抗生素后效应所使用方法的比较
J Antimicrob Chemother. 1994 Aug;34(2):223-30. doi: 10.1093/jac/34.2.223.
4
Susceptibility of Pseudomonas pseudomallei to some newer beta-lactam antibiotics and antibiotic combinations using time-kill studies.
J Antimicrob Chemother. 1994 Jan;33(1):145-9. doi: 10.1093/jac/33.1.145.
5
Postantibiotic effect of imipenem on gram-positive and gram-negative micro-organisms.亚胺培南对革兰氏阳性和革兰氏阴性微生物的抗生素后效应。
J Antimicrob Chemother. 1986 Dec;18 Suppl E:47-59. doi: 10.1093/jac/18.supplement_e.47.
6
The antimicrobial susceptibility of Pseudomonas pseudomallei. Emergence of resistance in vitro and during treatment.类鼻疽杆菌的抗菌药敏性。体外及治疗过程中耐药性的出现。
J Antimicrob Chemother. 1989 Sep;24(3):295-309. doi: 10.1093/jac/24.3.295.
7
Halving of mortality of severe melioidosis by ceftazidime.头孢他啶使重症类鼻疽死亡率减半。
Lancet. 1989 Sep 23;2(8665):697-701. doi: 10.1016/s0140-6736(89)90768-x.
8
Postantibiotic effects of imipenem, norfloxacin, and amikacin in vitro and in vivo.亚胺培南、诺氟沙星和阿米卡星的体外及体内抗生素后效应
Antimicrob Agents Chemother. 1989 Oct;33(10):1714-20. doi: 10.1128/AAC.33.10.1714.
9
The postantibiotic effect induced by antimicrobial combinations.抗菌药物联合使用所诱导的抗生素后效应。
Scand J Infect Dis Suppl. 1990;74:80-93.
10
Synergic post-antibiotic effect of amikacin in combination with beta-lactam antibiotics on gram-negative bacteria.阿米卡星与β-内酰胺类抗生素联合应用对革兰氏阴性菌的协同抗生素后效应
J Antimicrob Chemother. 1991 Jul;28(1):25-34. doi: 10.1093/jac/28.1.25.

抗生素后效应与类鼻疽伯克霍尔德菌（假单胞菌属）：当前治疗评估

Postantibiotic effects and Burkholderia (Pseudomonas) pseudomallei: evaluation of current treatment.

作者信息

Walsh A L, Smith M D, Wuthiekanun V, White N J

机构信息

Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

出版信息

Antimicrob Agents Chemother. 1995 Oct;39(10):2356-8. doi: 10.1128/AAC.39.10.2356.

DOI:10.1128/AAC.39.10.2356
PMID:8619598
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162945/
Abstract

The postantibiotic effects (PAEs) OF 16 antibiotics or antibiotic combinations currently used against Burkholderia (Pseudomonas) pseudomallei were determined. The beta-lactams had zero PAEs, while the carbapenems and ciprofloxacin induced median PAEs of 1 and 5 h, respectively. These results emphasize the need to maintain antibiotic levels above inhibitory concentrations in blood throughout the dosing interval in cases of severe melioidosis.

摘要

测定了目前用于对抗类鼻疽伯克霍尔德菌（假单胞菌属）的16种抗生素或抗生素组合的抗生素后效应（PAE）。β-内酰胺类抗生素的PAE为零，而碳青霉烯类抗生素和环丙沙星的中位PAE分别为1小时和5小时。这些结果强调，在严重类鼻疽病病例中，在整个给药间隔期间，需要将血液中的抗生素水平维持在高于抑制浓度的水平。