Stenström K, Leide-Svegborn S, Erlandsson B, Hellborg R, Mattsson S, Nilsson L E, Nosslin B, Skog G, Wiebert A
Department of Nuclear Physics, University of Lund, Sweden.
Appl Radiat Isot. 1996 Apr;47(4):417-22. doi: 10.1016/0969-8043(96)82298-6.
Long-term measurements of 14C in CO2 expired after ingestion of 14C-labelled triolein were performed using accelerator mass spectrometry (AMS). About 30% of a given amount of 14C-labelled triolein was catabolized rapidly, while the remaining 70% had a very slow turnover. The study shows the potential of the AMS technique for the study of the long-term biokinetics of 14C-labelled pharmaceuticals. The AMS technique allows the administered activity to be reduced by several orders of magnitude without compromising the study. It may also allow studies of rare drug metabolites.
使用加速器质谱法（AMS）对摄入14C标记的三油酸甘油酯后呼出的二氧化碳中的14C进行了长期测量。给定数量的14C标记的三油酸甘油酯中约30%被迅速分解代谢，而其余70%的周转非常缓慢。该研究显示了AMS技术在研究14C标记药物长期生物动力学方面的潜力。AMS技术能够在不影响研究的情况下将给药活性降低几个数量级。它还可能允许对罕见药物代谢物进行研究。
