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利弗莫尔生物加速器质谱法的发展与演变：一个视角

The development and evolution of biological AMS at Livermore: a perspective.

作者信息

Bench Graham

机构信息

Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA.

出版信息

Bioanalysis. 2025 Mar;17(5):345-354. doi: 10.1080/17576180.2025.2460391. Epub 2025 Feb 4.

DOI:10.1080/17576180.2025.2460391
PMID:39902785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11875510/
Abstract

Biological accelerator mass spectrometry (AMS) provides ultrasensitive carbon-14 isotopic analysis enabling a deeper understanding of human health concerns by enabling quantification of pharmacokinetics and other molecular endpoints directly in humans. It enables environmentally and human relevant studies of metabolic pathways through the use of very low concentrations of labeled metabolic substrates in cells and organisms. Here, we discuss why AMS is an important tool for the biosciences, the development and evolution of biological AMS at Livermore and discuss technical refinements that will improve the efficiency of operation for the measurement of ultra-trace levels of C, which, long term, will enable greater ease of use and sample throughput.

摘要

生物加速器质谱法（AMS）提供超灵敏的碳-14同位素分析，通过直接在人体中对药代动力学和其他分子终点进行定量，从而更深入地了解人类健康问题。它通过在细胞和生物体中使用极低浓度的标记代谢底物，实现了对代谢途径的环境和人体相关研究。在此，我们讨论了为什么AMS是生物科学的重要工具、劳伦斯利弗莫尔国家实验室生物AMS的发展与演进，并探讨了技术改进措施，这些改进将提高超痕量碳测量的操作效率，从长远来看，将使操作更加简便，提高样品通量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdef/11875510/064e67ad153b/IBIO_A_2460391_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdef/11875510/33713f12ad5a/IBIO_A_2460391_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdef/11875510/064e67ad153b/IBIO_A_2460391_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdef/11875510/33713f12ad5a/IBIO_A_2460391_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdef/11875510/064e67ad153b/IBIO_A_2460391_F0002_OC.jpg

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