Milani R V, Lavie C J
Department of Medicine, Ochsner Clinic, New Orleans, Louisiana, USA.
J Cardiopulm Rehabil. 1995 Nov-Dec;15(6):439-44. doi: 10.1097/00008483-199511000-00008.
To determine the the prevalence of isolated low high-density lipoprotein cholesterol and its response to hygienic therapy in coronary patients after major cardiac events.
Data before and after phase II cardiac rehabilitation and exercise training were assessed in 275 consecutive patients from two institutions. All patients had known coronary artery disease and underwent a 12-week program of aggressive hygienic therapy. The prevalence of isolated low high-density lipoprotein cholesterol in this cohort was determined and its response to vigorous nonpharmacologic therapy was assessed and compared with that of other coronary patients undergoing similar therapy.
At baseline, 113 (41%) had low high-density lipoprotein cholesterol, including 70 (25%) with isolated low high-density lipoprotein cholesterol. In contrast, 147 (53%) had "high-risk" low-density lipoprotein-cholesterol > or = 130 mg/dL. In the subgroup with isolated low high-density lipoprotein cholesterol, improvements occurred in body mass index, metabolic equivalents, high-density lipoprotein cholesterol, and low-density lipoprotein/high-density lipoprotein cholesterol. Compared with 205 patients without isolated low high-density lipoprotein cholesterol, this subgroup had much greater improvements in high-density lipoprotein cholesterol (+17% versus +2%; P < .001) and low-density lipoprotein/high-density lipoprotein cholesterol (-11% versus -6%; P < .02), with similar improvements in most other major coronary artery disease risk factors.
These results suggest that isolated low high-density lipoprotein cholesterol is prevalent in patients with coronary artery disease and is sensitive to aggressive hygienic interventions.
确定在发生重大心脏事件后的冠心病患者中单纯性低高密度脂蛋白胆固醇的患病率及其对卫生治疗的反应。
对来自两家机构的275例连续患者进行了心脏康复和运动训练II期前后的数据评估。所有患者均患有已知的冠状动脉疾病，并接受了为期12周的积极卫生治疗方案。确定该队列中单纯性低高密度脂蛋白胆固醇的患病率，并评估其对积极的非药物治疗的反应，并与接受类似治疗的其他冠心病患者进行比较。
基线时，113例（41%）患者高密度脂蛋白胆固醇水平低，其中70例（25%）为单纯性低高密度脂蛋白胆固醇。相比之下，147例（53%）患者的“高危”低密度脂蛋白胆固醇≥130mg/dL。在单纯性低高密度脂蛋白胆固醇亚组中，体重指数、代谢当量、高密度脂蛋白胆固醇以及低密度脂蛋白/高密度脂蛋白胆固醇均有所改善。与205例无单纯性低高密度脂蛋白胆固醇的患者相比，该亚组的高密度脂蛋白胆固醇改善更为显著（分别为+17%和+2%；P<.001），低密度脂蛋白/高密度脂蛋白胆固醇改善也更明显（分别为-11%和-6%；P<.02），大多数其他主要冠状动脉疾病危险因素也有类似改善。
这些结果表明，单纯性低高密度脂蛋白胆固醇在冠状动脉疾病患者中普遍存在，且对积极的卫生干预敏感。
