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治疗指南:炎症性肠病研究的最新进展

Signposts to therapy: recent advances in inflammatory bowel disease research.

作者信息

Hamilton J

出版信息

CMAJ. 1996 May 15;154(10):1513-6.

PMID:8625002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1487827/
Abstract

Research on ulcerative colitis and Crohn disease, the two conditions grouped under the heading of inflammatory bowel disease (IBD), is improving our understanding of how the intestine functions at the cellular level in health and disease. Researchers in the McGill Inflammatory Bowel Disease Research Program are studying the factors that affect the transport of nutrients, salt and water across cell membranes in the intestinal epithelium and investigating the cellular mechanisms of diarrhea. Their main interest is in how the intestine adapts in response to inflammation. Their findings promise to yield new targets for the pharmacologic and dietary management of IBD.

摘要

对溃疡性结肠炎和克罗恩病(这两种疾病归为炎症性肠病(IBD)范畴)的研究,正在增进我们对肠道在健康和疾病状态下细胞水平功能的理解。麦吉尔炎症性肠病研究项目的研究人员正在研究影响营养物质、盐和水在肠道上皮细胞膜间转运的因素,并探究腹泻的细胞机制。他们主要关注的是肠道如何对炎症做出适应性反应。他们的研究结果有望为炎症性肠病的药物治疗和饮食管理带来新的靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/033c/1487827/76d05cfd6d81/cmaj00094-0060-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/033c/1487827/76d05cfd6d81/cmaj00094-0060-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/033c/1487827/76d05cfd6d81/cmaj00094-0060-a.jpg

相似文献

1
Signposts to therapy: recent advances in inflammatory bowel disease research.治疗指南:炎症性肠病研究的最新进展
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2
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3
Immunologic and molecular mechanisms in inflammatory bowel disease.炎症性肠病的免疫和分子机制
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Gene transfer approaches for the treatment of inflammatory bowel disease.用于治疗炎症性肠病的基因转移方法。
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Genetic and spontaneous models of inflammatory bowel disease in rodents: evidence for abnormalities in mucosal immune regulation.啮齿动物炎症性肠病的遗传和自发模型:黏膜免疫调节异常的证据。
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Animal models of inflammatory bowel disease: lessons from enteric infections.炎症性肠病的动物模型:来自肠道感染的经验教训。
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Unravelling the pathogenesis of inflammatory bowel disease.揭示炎症性肠病的发病机制。
Nature. 2007 Jul 26;448(7152):427-34. doi: 10.1038/nature06005.
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The immune response in inflammatory bowel disease.炎症性肠病中的免疫反应。
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Understanding why probiotic therapies can be effective in treating IBD.了解益生菌疗法为何对治疗炎症性肠病有效。
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Role of animal models for the pathogenesis and treatment of inflammatory bowel disease.动物模型在炎症性肠病发病机制及治疗中的作用
Scand J Gastroenterol Suppl. 1997;223:99-104.

本文引用的文献

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Na(+)-K(+)-ATPase alpha 1- and beta 1-mRNA and protein levels in rat small intestine in experimental ileitis.实验性回肠炎大鼠小肠中Na(+)-K(+)-ATP酶α1和β1的mRNA及蛋白质水平
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Gastroenterology. 1989 Mar;96(3):795-803.
7
Inverse relationship between colonic (Na+ + K+)-ATPase activity and degree of mucosal inflammation in inflammatory bowel disease.炎症性肠病中结肠(钠+钾)-ATP酶活性与黏膜炎症程度之间的负相关关系。
Dig Dis Sci. 1988 Apr;33(4):417-22. doi: 10.1007/BF01536025.
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Alterations in quantitative distribution of Na,K-ATPase activity along crypt-villus axis in animal model of malabsorption characterized by hyperproliferative crypt cytokinetics.在以隐窝细胞动力学过度增殖为特征的吸收不良动物模型中,钠钾ATP酶活性沿隐窝-绒毛轴的定量分布变化。
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