Hamilton J
CMAJ. 1996 May 15;154(10):1513-6.
Research on ulcerative colitis and Crohn disease, the two conditions grouped under the heading of inflammatory bowel disease (IBD), is improving our understanding of how the intestine functions at the cellular level in health and disease. Researchers in the McGill Inflammatory Bowel Disease Research Program are studying the factors that affect the transport of nutrients, salt and water across cell membranes in the intestinal epithelium and investigating the cellular mechanisms of diarrhea. Their main interest is in how the intestine adapts in response to inflammation. Their findings promise to yield new targets for the pharmacologic and dietary management of IBD.
对溃疡性结肠炎和克罗恩病(这两种疾病归为炎症性肠病(IBD)范畴)的研究,正在增进我们对肠道在健康和疾病状态下细胞水平功能的理解。麦吉尔炎症性肠病研究项目的研究人员正在研究影响营养物质、盐和水在肠道上皮细胞膜间转运的因素,并探究腹泻的细胞机制。他们主要关注的是肠道如何对炎症做出适应性反应。他们的研究结果有望为炎症性肠病的药物治疗和饮食管理带来新的靶点。