Leung D Y
Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA.
Clin Exp Immunol. 1996 May;104 Suppl 1:49-54.
Kawasaki Syndrome (KS) is an acute multi-system vasculitis of infancy and early childhood associated with the development of coronary artery abnormalities. The prevalence of cardiovascular abnormalities can be significantly reduced by treating patients during the first 10 days of illness with high-dose intravenous immune globulin (IVIG). Despite the widely held belief that KS is caused by an infectious agent, the aetiology of this illness remains controversial. Recent immunological and microbiological studies suggest a potential role for staphylococcal and streptococcal toxins (superantigens) in the pathogenesis of KS. Confirmation of these findings could result in more effective diagnostic and therapeutic approaches for the treatment of this common cause of acquired heart disease in children.
川崎病（KS）是一种发生于婴幼儿和儿童早期的急性多系统血管炎，与冠状动脉异常的发展相关。在疾病的前10天用大剂量静脉注射免疫球蛋白（IVIG）治疗患者，可显著降低心血管异常的发生率。尽管人们普遍认为KS是由感染因子引起的，但这种疾病的病因仍存在争议。最近的免疫学和微生物学研究表明，葡萄球菌和链球菌毒素（超抗原）在KS的发病机制中可能起作用。这些发现的证实可能会为治疗儿童后天性心脏病的这一常见病因带来更有效的诊断和治疗方法。
