Coste A, Wang Q P, Roudot-Thoraval F, Chapelin C, Bedbeder P, Poron F, Peynègre R, Escudier E
Service d'ORL et de Chirurgue Cervico-Faciale, Hôpitaux Henri Mondor et Intercommunal de Créteil, France.
Laryngoscope. 1996 May;106(5 Pt 1):578-83. doi: 10.1097/00005537-199605000-00011.
The modifications of epithelial differentiation and proliferation observed in nasal polyps (NP) could be related to local secretion of growth factors, among which platelet-derived growth factor (PDGF) could play a key role. We therefore prospectively studied, by immunohistochemistry, proliferating cell nuclear antigen (PCNA, an S-phase cell marker), PDGF, and CD-68 (activated macrophages marker) expression in NP and inferior turbinate mucosa (NM) in 11 patients. Our data show that PCNA and PDGF expression are increased in NP epithelium, while CD-68 expression is increased in NP epithelium and lamina propria when compared to NM. Increased local PDGF secretion by numerous activated macrophages could therefore be involved in epithelial cell proliferation up-regulation in NP. PDGF could also be involved in the pathogenesis of NP via its connective tissue remodeling actions.
鼻息肉（NP）中观察到的上皮分化和增殖改变可能与生长因子的局部分泌有关，其中血小板衍生生长因子（PDGF）可能起关键作用。因此，我们通过免疫组织化学方法，对11例患者的鼻息肉和下鼻甲黏膜（NM）中增殖细胞核抗原（PCNA，一种S期细胞标志物）、PDGF和CD - 68（活化巨噬细胞标志物）的表达进行了前瞻性研究。我们的数据表明，与NM相比，NP上皮中PCNA和PDGF表达增加，而NP上皮和固有层中CD - 68表达增加。因此，大量活化巨噬细胞增加的局部PDGF分泌可能参与NP上皮细胞增殖上调。PDGF也可能通过其结缔组织重塑作用参与NP的发病机制。
