Oliver S G
Department of Biochemistry and Applied Molecular Biology, UMIST, Manchester, UK.
Nature. 1996 Feb 15;379(6566):597-600. doi: 10.1038/379597a0.
Genome sequencing is leading to the discovery of new genes at a rate 50-100 times greater than that achieved by classical genetics, but the biological function of almost half of these genes is completely unknown. In order fully to exploit genome sequence data, a systematic approach to the discovery of gene function is required. Possible strategies are discussed here in the context of functional analysis in the yeast Saccharomyces cerevisiae, a model eukaryote whose genome sequence will soon be completed.
基因组测序正以前所未有的速度发现新基因，其发现速度比传统遗传学快50到100倍，但几乎一半的这些基因的生物学功能却完全未知。为了充分利用基因组序列数据，需要一种系统的方法来发现基因功能。本文将在酵母（一种基因组序列即将完成的典型真核生物）功能分析的背景下讨论可能的策略。
