Hu H, Rutishauser U
Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-4955, USA.
Neuron. 1996 May;16(5):933-40. doi: 10.1016/s0896-6273(00)80116-6.
During mammalian brain development, immature neurons often migrate considerable distances. A dramatic example is the rostral migration of olfactory interneuron precursors from near the septum to the olfactory bulb via a subventricular pathway. Heterotopic transplantations establish that this migration is unidirectional and that guidance cues operate over a considerable distance. The guidance cues for this translocation have not been identified, and the present studies provide evidence that a diffusible chemorepulsive factor, secreted by caudal septum but not by other tissue regions surrounding the pathway, may be involved. This activity is functionally distinct from that produced by factors that influence vertebrate axon outgrowth, such as netrin-1, netrin-2, and collapsin-1/semaphorin-III. The presence of this activity in the floor plate/ventral spinal cord as well as the septum suggests that it may influence other types of cell migration.
在哺乳动物大脑发育过程中，未成熟神经元常常迁移相当长的距离。一个显著的例子是嗅觉中间神经元前体通过脑室下通路从靠近隔膜处向嗅球进行头端迁移。异位移植表明这种迁移是单向的，并且引导信号在相当长的距离上起作用。这种移位的引导信号尚未确定，而目前的研究提供了证据，表明一种由尾侧隔膜而非该通路周围其他组织区域分泌的可扩散化学排斥因子可能参与其中。这种活性在功能上与影响脊椎动物轴突生长的因子（如netrin-1、netrin-2和collapsin-1/信号素III）所产生的活性不同。这种活性在底板/腹侧脊髓以及隔膜中的存在表明它可能影响其他类型的细胞迁移。
