Pulatov A S, Glushko L F
Fiziol Zh SSSR Im I M Sechenova. 1977 Mar;63(3):652-7.
In chronic experiments on dogs, soon after ligation of the pancreatic duct, amylase increases in the peripheral blood as well as the total amylase and lipase release in liquid and solid portions of the secret from isolated parts of the small intestine. The alpha--amylase release was shown to depend on the level of the blood amylolytic activity and on secretory activity of small intestine. The alpha--amylase and lipase release is more increased at mechanical rather than at chemical stimulation of the small intestine. After the secretory function of the pancreas is excluded, two stages of compensatory--adaptive changes occur in the secretory activity of small intestine: first the compensation is due to less energy--consuming processes (recretion of the blood enzymes), and further the compensatory mechanisms of the small intestine become involved.
在对狗进行的慢性实验中,胰管结扎后不久,外周血中的淀粉酶增加,同时从小肠分离部分的分泌物的液体和固体部分中的总淀粉酶和脂肪酶释放也增加。已表明α-淀粉酶的释放取决于血液淀粉分解活性水平和小肠的分泌活性。在对小肠进行机械刺激而非化学刺激时,α-淀粉酶和脂肪酶的释放增加得更多。在排除胰腺的分泌功能后,小肠的分泌活动会发生两个阶段的代偿性适应变化:首先,代偿是由于耗能较少的过程(血液酶的再分泌),随后小肠的代偿机制开始起作用。