鼻咽癌中肿瘤相关组织嗜酸性粒细胞增多症的患病率及预后意义
Prevalence and prognostic significance of tumor-associated tissue eosinophilia in nasopharyngeal carcinoma.
作者信息
Leighton S E, Teo J G, Leung S F, Cheung A Y, Lee J C, van Hasselt C A
机构信息
Department of Surgery, Sir Y.K. Pao Cancer Centre, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
出版信息
Cancer. 1996 Feb 1;77(3):436-40. doi: 10.1002/(SICI)1097-0142(19960201)77:3<436::AID-CNCR3>3.0.CO;2-I.
BACKGROUND
Tumor-associated tissue eosinophilia (TATE) has been associated with an improved prognosis in a variety of neoplasms.
METHODS
Diagnostic biopsy specimens from 96 patients with nasopharyngeal carcinoma (NPC) were reviewed for the presence of TATE by an observer blinded to the patients' clinical histories. Comparisons between patients with and without TATE with respect to the probabilities of local recurrence, distant metastasis, and survival were performed using the log rank test on Kaplan-Meier product-limit estimates and the Cox proportional hazards model.
RESULTS
The prevalence of TATE in these patients was 32%, and was not significantly associated with local recurrence, distant metastasis, or survival.
CONCLUSIONS
These results are discordant with those of studies in other tumor models, although comparison is hampered by varying definitions of TATE. The differing results may be due to variations in the degree of activation of the eosinophils present in TATE in different tumors.
背景
肿瘤相关组织嗜酸性粒细胞增多症（TATE）与多种肿瘤预后改善相关。
方法
对96例鼻咽癌（NPC）患者的诊断性活检标本进行回顾，由对患者临床病史不知情的观察者检查是否存在TATE。采用Kaplan-Meier乘积限估计的对数秩检验和Cox比例风险模型，对有或无TATE的患者在局部复发、远处转移和生存概率方面进行比较。
结果
这些患者中TATE的患病率为32%，与局部复发、远处转移或生存无显著相关性。
结论
尽管TATE的不同定义妨碍了比较，但这些结果与其他肿瘤模型的研究结果不一致。结果不同可能是由于不同肿瘤中TATE中存在的嗜酸性粒细胞激活程度不同。
Zotero 插件