Murakami S, Nara Y, Yamori Y
Medicinal Research Laboratory, Taisho Pharmaceutical Co. Ltd., Saitama, Japan.
Life Sci. 1996;58(19):1643-51. doi: 10.1016/0024-3205(96)00139-7.
The effects of taurine on the regression of pre-established hypercholesterolemia were examined in stroke-prone spontaneously hypertensive rats (SHRSP). Hypercholesterolemia was induced by feeding a hypercholesterolemic diet to SHRSP for 30 days. Then, the diet was switched to normal chow with or without 3% taurine, and the effects were followed up for another 30 days. During regression serum cholesterol level was rapidly decreased, and was accelerated by taurine. A similar accelerated decrease in cholesterol content by taurine was seen also in tissues including the liver, intestine, and aorta. In the liver, acyl-CoA:cholesterol acyltransferase (ACAT) activity was significantly low in the taurine-supplemented group, parallel with the hepatic cholesteryl ester content. On the other hand, hepatic cholesterol 7 alpha-hydoxylase activity maintained a higher level in the taurine-supplemented group. These results showed that taurine accelerates the regression of hypercholesterolemia, and suggested that this effect is related to the increase in cholesterol catabolism to bile acid through the enhancement of 7 alpha-hydoxylase activity.
在易患中风的自发性高血压大鼠（SHRSP）中研究了牛磺酸对已建立的高胆固醇血症消退的影响。通过给SHRSP喂食高胆固醇饮食30天来诱导高胆固醇血症。然后，将饮食换成含或不含3%牛磺酸的正常食物，并持续观察30天。在消退过程中，血清胆固醇水平迅速下降，且牛磺酸能加速这一过程。在包括肝脏、肠道和主动脉在内的组织中，牛磺酸也能使胆固醇含量出现类似的加速下降。在肝脏中，补充牛磺酸的组中酰基辅酶A：胆固醇酰基转移酶（ACAT）活性显著降低，与肝脏胆固醇酯含量平行。另一方面，补充牛磺酸的组中肝脏胆固醇7α-羟化酶活性维持在较高水平。这些结果表明，牛磺酸能加速高胆固醇血症的消退，并提示这种作用与通过增强7α-羟化酶活性使胆固醇分解为胆汁酸增加有关。
