Baylies M K, Bate M
Department of Zoology, University of Cambridge, UK.
Science. 1996 Jun 7;272(5267):1481-4. doi: 10.1126/science.272.5267.1481.
Somatic muscle is derived from a subset of embryonic mesoderm. In Drosophila, Twist (Twi), a basic helix-loop-helix transcription factor, is a candidate regulator of mesodermal differentiation and myogenesis. Altering amounts of Twist after gastrulation revealed that high levels of Twist are required for somatic myogenesis and block the formation of other mesodermal derivatives. Expression of twist in the ectoderm drives these cells into myogenesis. Thus, after an initial role in gastrulation, twist regulates mesodermal differentiation and propels a specific subset of mesodermal cells into somatic myogenesis. Vertebrate homologs of twist may also participate in the subdivision of mesoderm.
体壁肌源自胚胎中胚层的一个亚群。在果蝇中，Twist（Twi）是一种碱性螺旋-环-螺旋转录因子，是中胚层分化和肌发生的候选调节因子。原肠胚形成后改变Twist的量表明，高水平的Twist是体壁肌发生所必需的，并会阻止其他中胚层衍生物的形成。外胚层中twist的表达促使这些细胞进入肌发生过程。因此，在原肠胚形成中起初始作用后，twist调节中胚层分化，并促使中胚层细胞的一个特定亚群进入体壁肌发生过程。Twist的脊椎动物同源物也可能参与中胚层的细分。
