Harrington P J, Schmidt N B, Telch M J
University of Texas at Austin 78712, USA.
Am J Psychiatry. 1996 Jun;153(6):823-5. doi: 10.1176/ajp.153.6.823.
The authors examined the effect of panic provocation on the subsequent development of panic attacks and panic disorder in nonclinical subjects with no history of spontaneous panic.
Sixty-two subjects who had completed a study examining fearful responses to a single vital capacity inhalation of 35% CO2 were reevaluated 1 year following the challenge test.
Challenge-induced panic was not related to the later development of panic or panic disorder. According to the Structured Clinical Interview for DSM-III-R--Non-Patient Edition, none of the subjects met DSM-III-R criteria for panic disorder and only six subjects reported spontaneous panic during the year after panic provocation. Of the six subjects who experienced spontaneous panic, two had panicked in response to the CO2 challenge.
The experimental provocation of panic in nonclinical subjects appears to be a safe research paradigm for exploring the psychopathogenicity of panic disorder.
作者研究了惊恐激发对无自发性惊恐发作史的非临床受试者随后发生惊恐发作和惊恐障碍的影响。
对62名完成了一项关于对单次吸入35%二氧化碳肺活量产生恐惧反应研究的受试者，在激发试验1年后进行重新评估。
激发诱导的惊恐与随后惊恐或惊恐障碍的发生无关。根据《精神障碍诊断与统计手册》第三版修订版非患者版的结构化临床访谈，没有受试者符合惊恐障碍的《精神障碍诊断与统计手册》第三版修订版标准，只有6名受试者在惊恐激发后的一年中报告有自发性惊恐发作。在经历自发性惊恐发作的6名受试者中，有2名对二氧化碳激发产生了惊恐反应。
在非临床受试者中进行惊恐的实验性激发似乎是探索惊恐障碍心理致病性的一种安全的研究范式。
