Li D K, Mueller B A, Hickok D E, Daling J R, Fantel A G, Checkoway H, Weiss N S
Department of Epidemiology, University of Washington, Seattle, USA.
Am J Public Health. 1996 Feb;86(2):249-53. doi: 10.2105/ajph.86.2.249.
To study maternal smoking during pregnancy and the risk of congenital urinary tract anomalies, we interviewed mothers of 118 affected infants born to residents of western Washington State during 1990 and 1991 and mothers of 369 control infants randomly selected from those without birth defects delivered during those years in five hospitals in King County, Washington. Maternal smoking was associated with an increased risk of congenital urinary tract anomalies in offspring (adjusted odds ratio [OR] = 2.3; 95% confidence interval [CI] = 1.2, 4.5). This risk was higher among light smokers (1-1000 cigarettes during the pregnancy) (OR = 3.7; 95% CI = 1.7, 8.6) than among heavy smokers (OR = 1.4; 95% CI = 0.6, 3.3). Our results corroborate previous findings and support the hypothesis of a causal relation.
为研究孕期母亲吸烟与先天性泌尿系统异常的风险,我们采访了1990年和1991年在华盛顿州西部出生的118名患先天性泌尿系统异常婴儿的母亲,以及从华盛顿州金县五家医院在这些年份出生的无出生缺陷婴儿中随机选取的369名对照婴儿的母亲。母亲吸烟与后代先天性泌尿系统异常风险增加相关(校正比值比[OR]=2.3;95%置信区间[CI]=1.2,4.5)。这种风险在轻度吸烟者(孕期吸烟1 - 1000支)中(OR = 3.7;95% CI = 1.7,8.6)高于重度吸烟者(OR = 1.4;95% CI = 0.6,3.3)。我们的结果证实了先前的发现,并支持因果关系的假设。