Vázquez-Barquero J L, Cuesta Núñez M J, Quintana Pando F, de la Varga M, Herrera Castanedo S, Dunn G
Social Psychiatry Research Unit of Cantabria, University Hospital Marqués de Valdecillá, Cantabria University, Santander, Spain.
Psychol Med. 1995 Nov;25(6):1247-57. doi: 10.1017/s0033291700033213.
This paper examines structural brain abnormalities, as evaluated by the CT scan, in first episodes of schizophrenia and their association with sociodemographic, diagnostic and clinical variables. The investigation included all patients with a first episode of schizophrenia who, over a 2-year period, made contact with any of the public mental health services of the Autonomous Region of Cantabria in Northern Spain. Diagnostic and clinical characteristics were evaluated through the use of the Spanish version of the Present State Examination (PSE-9) and the Scales for the Assessment of Positive and Negative Symptoms (SANS and SAPS respectively). The study demonstrated the presence of structural brain abnormalities in this sample of first episode schizophrenics. These abnormalities were mainly expressed in the presence of larger VBR for schizophrenic patients than in the controls, these findings being more marked in women than in men. We failed to reveal, however, any evidence of an association of these brain abnormalities with diagnostic or clinical characteristics.
本文通过CT扫描评估首次发作的精神分裂症患者的脑结构异常情况，并探讨其与社会人口统计学、诊断及临床变量之间的关联。该研究纳入了所有首次发作的精神分裂症患者，这些患者在两年时间内与西班牙北部坎塔布里亚自治区的任何公共精神卫生服务机构有过接触。通过使用西班牙语版的《现状检查》（PSE-9）以及《阳性和阴性症状评定量表》（分别为SANS和SAPS）来评估诊断和临床特征。研究表明，在首次发作的精神分裂症患者样本中存在脑结构异常。这些异常主要表现为精神分裂症患者的脑体积比对照组更大，且这些发现女性比男性更为明显。然而，我们未能发现这些脑异常与诊断或临床特征之间存在关联的任何证据。
