Johansen M V, Monrad J, Christensen N O
Danish Biharziasis Laboratory, Charlottenlund, Denmark.
Vet Parasitol. 1996 Mar;62(1-2):83-91. doi: 10.1016/0304-4017(95)00849-7.
The effect of praziquantel against experimental Schistosoma bovis infection in West African Dwarf goats was investigated. Thirty goats were exposed to 2000 cercariae each and 15 of those received a praziquantel treatment (60 mg kg-1) 13 weeks post-infection. One day, 1 week and 4 weeks post-treatment representative goats from each group were killed and worms were recovered by perfusion. For comparison, parasite-free control animals were monitored, some of which were given praziquantel. Every second week during the study, faecal samples were collected. The cure rate was 100% 1 day, 99.4% 1 week and 95.7% 4 weeks post-treatment. Tissue egg counts were significantly reduced (P < 0.001) 4 weeks post-treatment in all parts of the intestines, but not in the liver. Faecal egg counts were reduced by 84.1% 1 week and by 98.3% 3 weeks after treatment, the reduction being highly significant both 1 week 3 weeks after treatment (P < 0.001). Overall strong correlations between the number of worm pairs, tissue egg counts and the final faecal egg count were observed, indicating that the faecal egg counts during infection and following treatment can be used as a guideline for the pathology associated with the infection.
研究了吡喹酮对西非矮山羊实验性牛血吸虫感染的效果。30只山羊每只接触2000条尾蚴，其中15只在感染后13周接受吡喹酮治疗（60毫克/千克）。治疗后1天、1周和4周，每组选取代表性山羊处死，通过灌注回收虫体。为作比较，监测了无寄生虫的对照动物，其中一些给予了吡喹酮。在研究期间，每隔一周采集粪便样本。治疗后1天治愈率为100%，1周为99.4%，4周为95.7%。治疗后4周，肠道各部位的组织虫卵计数显著降低（P<0.001），但肝脏中的虫卵计数未降低。治疗后1周粪便虫卵计数降低了84.1%，3周降低了98.3%，治疗后1周和3周的降低均极显著（P<0.001）。观察到虫体对数、组织虫卵计数和最终粪便虫卵计数之间总体存在强相关性，表明感染期间和治疗后的粪便虫卵计数可作为与感染相关病理学的指导指标。
