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本文引用的文献

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Hypoalgesic effect of EMLA and lidocaine gel applied on human oral mucosa: quantitative evaluation by sensory and pain thresholds to argon laser stimulation.复方利多卡因乳膏和利多卡因凝胶对人口腔黏膜的镇痛作用:通过对氩激光刺激的感觉阈值和疼痛阈值进行定量评估
Anesth Prog. 1992;39(1-2):4-8.
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Oral mucosal analgesia quantitatively assessed by argon laser-induced thresholds and single-evoked vertex potentials.通过氩激光诱导阈值和单次诱发顶点电位对口腔黏膜镇痛进行定量评估。
Anesth Pain Control Dent. 1993 Summer;2(3):154-61.
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The neurobiology of facial and dental pain: present knowledge, future directions.面部与牙齿疼痛的神经生物学:当前认知与未来方向
J Dent Res. 1987 May;66(5):962-81. doi: 10.1177/00220345870660052201.
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Evaluation of treatment at a dental fears research clinic.牙科恐惧研究诊所的治疗评估。
Spec Care Dentist. 1987 May-Jun;7(3):130-4. doi: 10.1111/j.1754-4505.1987.tb00622.x.
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Manifestations, acquisition and diagnostic categories of dental fear in a self-referred population.自我转诊人群中牙科恐惧的表现、成因及诊断类别
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Psychophysical measurement on pain perception after administration of a topical anesthetic.局部麻醉药给药后疼痛感知的心理物理学测量。
Quintessence Int. 1991 Apr;22(4):311-5.
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Topical application of 5% eutectic mixture of lignocaine and prilocaine (EMLA) before removal of arch bars.在拆除牙弓夹板前局部应用5%利多卡因和丙胺卡因的共熔混合物(EMLA)。
Br J Oral Maxillofac Surg. 1992 Jun;30(3):153-6. doi: 10.1016/0266-4356(92)90146-a.
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Anesthetic effect of EMLA occluded with Orahesive oral bandages on oral mucosa. A placebo-controlled study.用口腔粘贴绷带封闭的EMLA对口腔黏膜的麻醉效果:一项安慰剂对照研究。
Anesth Prog. 1992;39(3):79-82.
9
Narcotic analgesia: fentanyl reduces the intensity but not the unpleasantness of painful tooth pulp sensations.麻醉性镇痛:芬太尼可减轻牙髓疼痛感觉的强度,但不能减轻其不适感。
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A double-blind crossover comparison of topical anesthetics.局部麻醉剂的双盲交叉比较。
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一种局部麻醉剂在龈袋刮治过程中对疼痛及不适感的疗效。

Efficacy of a topical anesthetic on pain and unpleasantness during scaling of gingival pockets.

作者信息

Svensson P, Petersen J K, Svensson H

机构信息

Department of Prosthetic Dentistry and Stomatognathic Physiology, Royal Dental College, Aarhus University, Denmark.

出版信息

Anesth Prog. 1994;41(2):35-9.

PMID:8638858
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2148810/
Abstract

The efficacy of a topical anesthetic on pain and unpleasantness provoked by scaling of gingival pockets was investigated in 20 patients with mild chronic periodontitis. A eutectic mixture of local anesthetics (EMLA) and a placebo cream, both occluded by Orahesive Oral Bandages, were applied in a balanced, randomized, double-blind, split-mouth design, which enabled within-subject comparison of the anesthetic and the placebo in the upper and the lower jaw. Pretreatment interviews showed that approximately two-thirds of the patients considered gingival scaling to be associated with some degree of pain and unpleasantness. Pain intensity and unpleasantness were evaluated on 100-mm visual analog scales (VAS). Application of EMLA reduced both pain intensity and unpleasantness significantly compared to placebo cream. Median reductions in VAS pain intensity in the upper and lower jaw were 58.9% and 61.9%, and corresponding reductions in VAS unpleasantness were 31.9% and 25.6%, respectively. Generally, the patients accepted the anesthetic procedure well. The residual perception of pain and unpleasantness following topical anesthesia may be dependent on activation of nonanesthetized nociceptive fibers in the tooth pulp. However, the present study clearly demonstrates the efficacy of a topical anesthetic in a clinical situation, which may be recommended as a simple pharmacologic strategy to reduce pain and unpleasantness during scaling procedures.

摘要

在20名轻度慢性牙周炎患者中,研究了一种局部麻醉剂对龈袋刮治引起的疼痛和不适感的疗效。采用一种平衡、随机、双盲、分口设计,将局部麻醉剂的共晶混合物(EMLA)和安慰剂乳膏均用口腔绷带封闭,从而能够在上下颌内对麻醉剂和安慰剂进行受试者自身对照。治疗前访谈显示,约三分之二的患者认为龈下刮治会伴有一定程度的疼痛和不适感。疼痛强度和不适感通过100毫米视觉模拟量表(VAS)进行评估。与安慰剂乳膏相比,应用EMLA可显著降低疼痛强度和不适感。上下颌VAS疼痛强度的中位数降低分别为58.9%和61.9%,相应的VAS不适感降低分别为31.9%和25.6%。总体而言,患者对麻醉程序的接受度良好。局部麻醉后残留的疼痛和不适感可能取决于牙髓中未麻醉的伤害性纤维的激活。然而,本研究清楚地证明了局部麻醉剂在临床情况下的疗效,这可作为一种简单的药理学策略推荐用于减少刮治过程中的疼痛和不适感。