Svensson P, Petersen J K
Department of Prosthetic Dentistry and Stomatognathic Physiology, Royal Dental College, University of Aarhus, Denmark.
Anesth Prog. 1992;39(3):79-82.
The efficiency of a topical anesthetic occluded with Orahesive Oral Bandage was investigated. Experimental pain was provoked by needle insertions into two palatal test areas in 20 healthy subjects. Pain, estimated on a 100-mm visual analogue scale (VAS), decreased significantly from 23.5 mm to 10.5 mm at the greater palatine foramen and from 51.5 mm to 35.0 mm at the incisive foramen after application of a eutectic mixture of local anesthetics (EMLA). No significant change in pain perception was obtained after placebo application. The EMLA cream and the Orahesive Oral Bandages were well accepted by the subjects, as only two out of 20 subjects experienced slight gagging reflexes and only three considered the taste unpleasant. No other adverse reactions were observed. Occlusion of topical anesthetics seems to be a useful technique for achieving superficial mucosal anesthesia.
研究了用口腔粘贴绷带封闭的局部麻醉剂的效果。在20名健康受试者的两个腭部测试区域进行针刺以引发实验性疼痛。在应用局部麻醉剂的共熔混合物（EMLA）后，在100毫米视觉模拟量表（VAS）上估计的疼痛在腭大孔处从23.5毫米显著降低至10.5毫米，在切牙孔处从51.5毫米显著降低至35.0毫米。应用安慰剂后，疼痛感知无显著变化。受试者对EMLA乳膏和口腔粘贴绷带的接受度良好，因为20名受试者中只有2人经历了轻微的 gag反射，只有3人认为味道不佳。未观察到其他不良反应。封闭局部麻醉剂似乎是实现浅表粘膜麻醉的一种有用技术。
