Saini J S, Mittal S
Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Arch Ophthalmol. 1996 Jun;114(6):649-53. doi: 10.1001/archopht.1996.01100130641001.
To evaluate in vivo corneal endothelial function in patients with non-insulin-dependent diabetes mellitus with or without diabetic retinopathy.
In age-matched samples of 45 eyes of diabetic patients and 15 eyes of healthy control subjects, corneal endothelial function was evaluated by using pachometric measurements of the cornea following hydrophilic contact lens wear of low oxygen transmissibility. Corneal deswelling regression was quantitated to arrive at the percentage recovery per hour as an index of endothelial function. The status of retinopathy was determined in diabetic patients by using standard criteria.
In patients with diabetes mellitus and diabetic retinopathy, the assessed mean (+/- SD) value for the percentage recovery per hour following contact lens-induced edema was 40.03% +/- 7.27%, which was significantly lower than in eyes without changes of diabetic retinopathy (54.31% +/- 6.88%). Also, diabetic patients without retinopathy had a significantly lower percentage recovery per hour than did healthy control subjects (65.27% +/- 12.02%).
This study demonstrates significantly lower corneal endothelial function in patients with non-insulin-dependent diabetes mellitus and thus suggests a higher potential to decompensate following any deleterious stress.
评估非胰岛素依赖型糖尿病患者伴或不伴糖尿病视网膜病变时的体内角膜内皮功能。
在年龄匹配的样本中，对45只糖尿病患者的眼睛和15只健康对照者的眼睛进行研究。在佩戴低氧透过性亲水性隐形眼镜后，通过角膜厚度测量来评估角膜内皮功能。对角膜消肿回归进行定量，得出每小时的恢复百分比，作为内皮功能的指标。采用标准标准确定糖尿病患者的视网膜病变状态。
在患有糖尿病和糖尿病视网膜病变的患者中，隐形眼镜诱导水肿后每小时恢复百分比的评估均值（±标准差）为40.03%±7.27%，显著低于无糖尿病视网膜病变改变的眼睛（54.31%±6.88%）。此外，无视网膜病变的糖尿病患者每小时的恢复百分比也显著低于健康对照者（65.27%±12.02%）。
本研究表明非胰岛素依赖型糖尿病患者的角膜内皮功能显著降低，因此提示在任何有害应激后有更高的失代偿可能性。
