Finlay P M, Richardson M D, Robertson A G
West of Scotland Regional Unit of Oral and Maxillofacial Surgery, Canniesburn Hospital, Glasgow.
Br J Oral Maxillofac Surg. 1996 Feb;34(1):23-5. doi: 10.1016/s0266-4356(96)90130-8.
Radiotherapy given during treatment of oral and pharyngeal malignancy is frequently associated with colonization of the oral mucosa by Candida species. Treatment of these infections has included topical and systemic agents. In the present study 73 patients with oropharyngeal candidosis were treated with either amphotericin B (10 mg lozenges, four times daily for 14 days, 36 patients) or fluconazole (50 mg daily for 7 days, 37 patients). The yeasts most frequently isolated were C albicans and C glabrata. Clinical signs and symptoms showed improvement at end of treatment in 72% of patients who received amphotericin B compared with 92% of patients who received fluconazole. Mycological cure at end of treatment was achieved in 31% of the amphotericin B group and 46% of patients who received fluconazole. For both treatments the cure rate was less in denture wearers than in non denture wearers.
口腔和咽恶性肿瘤治疗期间进行的放射治疗常与念珠菌属在口腔黏膜定植相关。这些感染的治疗包括局部用药和全身用药。在本研究中，73例口咽念珠菌病患者接受了两性霉素B（10mg含片，每日4次，共14天，36例患者）或氟康唑（每日50mg，共7天，37例患者）治疗。最常分离出的酵母菌是白色念珠菌和光滑念珠菌。接受两性霉素B治疗的患者中，72%在治疗结束时临床体征和症状有所改善，而接受氟康唑治疗的患者中这一比例为92%。两性霉素B组31%的患者和接受氟康唑治疗的患者中46%在治疗结束时实现了真菌学治愈。两种治疗方法中，佩戴假牙者的治愈率均低于未佩戴假牙者。
