酒精性肝病患者的循环免疫复合物和补体浓度
Circulating immune complexes and complement concentrations in patients with alcoholic liver disease.
作者信息
Gluud C, Jans H
出版信息
J Clin Pathol. 1982 Apr;35(4):380-4. doi: 10.1136/jcp.35.4.380.
A prospective evaluation of circulating immune complexes (CIC) and the activity of the complement system was undertaken in 53 alcoholic patients just before diagnostic liver biopsy. Circulating immune complexes were detected in 39% of patients with alcoholic steatosis (n = 26), 58% of patients with alcoholic hepatitis (n = 12), and 60% of patients with alcoholic cirrhosis (n = 15). No significant difference was found between the three group of patients. The activity of the complement system was within reference limits in the majority of patients and only slight differences were detected between the three groups. No significant differences were observed in liver biochemistry and complement concentrations in CIC-positive and CIC-negative patients. Detection of CIC in patients with alcoholic liver disease does not seem to be of any diagnostic value or play any pathogenic role. The high prevalence of CIC in these patients may be due to a depressing effect of ethanol on clearance of CIC or to increased immunological reactivity, or to both.
在53例酒精性肝病患者进行诊断性肝活检前，对其循环免疫复合物（CIC）和补体系统活性进行了前瞻性评估。在酒精性脂肪变性患者（n = 26）中，39%检测到循环免疫复合物；酒精性肝炎患者（n = 12）中，58%检测到；酒精性肝硬化患者（n = 15）中，60%检测到。三组患者之间未发现显著差异。大多数患者的补体系统活性在参考范围内，三组之间仅检测到轻微差异。CIC阳性和CIC阴性患者的肝脏生化指标和补体浓度未观察到显著差异。酒精性肝病患者中CIC的检测似乎没有任何诊断价值，也不发挥任何致病作用。这些患者中CIC的高患病率可能是由于乙醇对CIC清除的抑制作用，或免疫反应性增加，或两者兼而有之。
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