• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
The newly identified yeast GRD genes are required for retention of late-Golgi membrane proteins.新鉴定出的酵母GRD基因是晚期高尔基体膜蛋白滞留所必需的。
Mol Cell Biol. 1996 Jun;16(6):2700-7. doi: 10.1128/MCB.16.6.2700.
2
Retrieval of resident late-Golgi membrane proteins from the prevacuolar compartment of Saccharomyces cerevisiae is dependent on the function of Grd19p.从酿酒酵母的液泡前区室中回收晚期高尔基体膜驻留蛋白取决于Grd19p的功能。
J Cell Biol. 1998 Feb 9;140(3):577-90. doi: 10.1083/jcb.140.3.577.
3
Two separate signals act independently to localize a yeast late Golgi membrane protein through a combination of retrieval and retention.两个独立的信号通过回收和保留机制共同作用，独立地将酵母晚期高尔基体膜蛋白定位到特定位置。
J Cell Biol. 1997 Jan 27;136(2):287-97. doi: 10.1083/jcb.136.2.287.
4
The yeast VPS5/GRD2 gene encodes a sorting nexin-1-like protein required for localizing membrane proteins to the late Golgi.酵母VPS5/GRD2基因编码一种将膜蛋白定位到晚期高尔基体所需的分选连接蛋白1样蛋白。
J Cell Sci. 1997 May;110 ( Pt 9):1063-72. doi: 10.1242/jcs.110.9.1063.
5
The membrane protein alkaline phosphatase is delivered to the vacuole by a route that is distinct from the VPS-dependent pathway.膜蛋白碱性磷酸酶通过一条与VPS依赖性途径不同的途径被转运至液泡。
J Cell Biol. 1997 Aug 11;138(3):531-45. doi: 10.1083/jcb.138.3.531.
6
Membrane protein retention in the yeast Golgi apparatus: dipeptidyl aminopeptidase A is retained by a cytoplasmic signal containing aromatic residues.膜蛋白在酵母高尔基体中的保留：二肽基氨肽酶A通过含芳香族残基的胞质信号被保留。
J Cell Biol. 1993 Jun;121(6):1197-209. doi: 10.1083/jcb.121.6.1197.
7
Vps52p, Vps53p, and Vps54p form a novel multisubunit complex required for protein sorting at the yeast late Golgi.Vps52p、Vps53p和Vps54p形成一种新型多亚基复合物，这是酵母晚期高尔基体中蛋白质分选所必需的。
Mol Biol Cell. 2000 Jan;11(1):305-23. doi: 10.1091/mbc.11.1.305.
8
Novel Golgi to vacuole delivery pathway in yeast: identification of a sorting determinant and required transport component.酵母中从高尔基体到液泡的新型运输途径：分选决定因素和所需运输成分的鉴定
EMBO J. 1997 May 15;16(10):2769-82. doi: 10.1093/emboj/16.10.2769.
9
Multiple sorting pathways between the late Golgi and the vacuole in yeast.酵母中晚期高尔基体与液泡之间的多种分选途径。
Biochim Biophys Acta. 1998 Aug 14;1404(1-2):211-30. doi: 10.1016/s0167-4889(98)00058-5.
10
Sorting of yeast membrane proteins into an endosome-to-Golgi pathway involves direct interaction of their cytosolic domains with Vps35p.酵母膜蛋白分选进入内体到高尔基体途径涉及它们的胞质结构域与Vps35p的直接相互作用。
J Cell Biol. 2000 Oct 16;151(2):297-310. doi: 10.1083/jcb.151.2.297.

引用本文的文献

1
Protein Phosphatases 2A Affects Drug Resistance of Candida albicans Biofilm Via ATG Protein Phosphorylation Induction.蛋白磷酸酶2A通过诱导自噬相关蛋白磷酸化影响白色念珠菌生物膜的耐药性。
Int Dent J. 2025 Aug 29;75(6):103873. doi: 10.1016/j.identj.2025.103873.
2
Autophagy Alters the Susceptibility of Biofilms to Antifungal Agents.自噬改变生物膜对抗真菌剂的敏感性。
Microorganisms. 2023 Aug 5;11(8):2015. doi: 10.3390/microorganisms11082015.
3
Asgard archaea shed light on the evolutionary origins of the eukaryotic ubiquitin-ESCRT machinery.古菌 Asgard 揭示了真核生物泛素-ESCRT 机制的进化起源。
Nat Commun. 2022 Jun 13;13(1):3398. doi: 10.1038/s41467-022-30656-2.
4
α-synuclein inhibits Snx3-retromer retrograde trafficking of the conserved membrane-bound proprotein convertase Kex2 in the secretory pathway of Saccharomyces cerevisiae.α-突触核蛋白抑制酿酒酵母分泌途径中保守的膜结合前蛋白转化酶 Kex2 的 Snx3-逆行转运体逆行转运。
Hum Mol Genet. 2022 Mar 3;31(5):705-717. doi: 10.1093/hmg/ddab284.
5
The Fusarium oxysporum gnt2, encoding a putative N-acetylglucosamine transferase, is involved in cell wall architecture and virulence.尖孢镰刀菌 gnt2，编码一个假定的 N-乙酰葡萄糖胺转移酶，参与细胞壁结构和毒力。
PLoS One. 2013 Dec 27;8(12):e84690. doi: 10.1371/journal.pone.0084690. eCollection 2013.
6
pH-dependent cargo sorting from the Golgi.pH 依赖性的高尔基体货物分拣。
J Biol Chem. 2011 Mar 25;286(12):10058-65. doi: 10.1074/jbc.M110.197889. Epub 2011 Jan 14.
7
Zinc status and vacuolar zinc transporters control alkaline phosphatase accumulation and activity in Saccharomyces cerevisiae.锌状态和液泡锌转运蛋白控制酿酒酵母中碱性磷酸酶的积累和活性。
Mol Microbiol. 2009 Apr;72(2):320-34. doi: 10.1111/j.1365-2958.2009.06644.x. Epub 2009 Mar 3.
8
Functional genomics of monensin sensitivity in yeast: implications for post-Golgi traffic and vacuolar H+-ATPase function.酵母中莫能菌素敏感性的功能基因组学：对高尔基体后转运和液泡H⁺-ATP酶功能的影响
Mol Genet Genomics. 2008 Sep;280(3):233-48. doi: 10.1007/s00438-008-0359-9. Epub 2008 Jul 9.
9
Structural features of vps35p involved in interaction with other subunits of the retromer complex.参与与回收体复合物其他亚基相互作用的vps35p的结构特征。
Traffic. 2007 Dec;8(12):1841-1853. doi: 10.1111/j.1600-0854.2007.00659.x. Epub 2007 Oct 17.
10
Skp1p regulates Soi3p/Rav1p association with endosomal membranes but is not required for vacuolar ATPase assembly.Skp1p调节Soi3p/Rav1p与内体膜的结合，但对于液泡ATP酶组装并非必需。
Eukaryot Cell. 2006 Dec;5(12):2104-13. doi: 10.1128/EC.00347-05. Epub 2006 Oct 13.

本文引用的文献

1
TGN38/41: a molecule on the move.TGN38/41：一个处于动态变化的分子。
Trends Cell Biol. 1993 Aug;3(8):252-5. doi: 10.1016/0962-8924(93)90046-4.
2
The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization.液泡蛋白分选受体Vps10p的胞质尾域和VPS基因产物的一个子集调节受体的稳定性、功能和定位。
Mol Biol Cell. 1995 Sep;6(9):1089-102. doi: 10.1091/mbc.6.9.1089.
3
Membrane protein retention in the yeast Golgi apparatus: dipeptidyl aminopeptidase A is retained by a cytoplasmic signal containing aromatic residues.膜蛋白在酵母高尔基体中的保留：二肽基氨肽酶A通过含芳香族残基的胞质信号被保留。
J Cell Biol. 1993 Jun;121(6):1197-209. doi: 10.1083/jcb.121.6.1197.
4
Oligomerization of a membrane protein correlates with its retention in the Golgi complex.膜蛋白的寡聚化与其在高尔基体复合物中的滞留相关。
J Cell Biol. 1993 Sep;122(6):1185-96. doi: 10.1083/jcb.122.6.1185.
5
Mutational analysis of the human KDEL receptor: distinct structural requirements for Golgi retention, ligand binding and retrograde transport.人类KDEL受体的突变分析：高尔基体保留、配体结合和逆向转运的不同结构要求。
EMBO J. 1993 Jul;12(7):2821-9. doi: 10.1002/j.1460-2075.1993.tb05943.x.
6
Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptors.酵母信息素受体胞吞作用所需的顺式和反式作用功能。
J Cell Biol. 1993 Jul;122(1):53-65. doi: 10.1083/jcb.122.1.53.
7
Kin recognition. A model for the retention of Golgi enzymes.亲缘识别。一种高尔基体酶保留的模型。
FEBS Lett. 1993 Sep 6;330(1):1-4. doi: 10.1016/0014-5793(93)80906-b.
8
Vps1p, a member of the dynamin GTPase family, is necessary for Golgi membrane protein retention in Saccharomyces cerevisiae.Vps1p是发动蛋白GTP酶家族的一员，对于酿酒酵母中高尔基体膜蛋白的保留是必需的。
EMBO J. 1993 Aug;12(8):3049-59. doi: 10.1002/j.1460-2075.1993.tb05974.x.
9
Targeting and retention of Golgi membrane proteins.高尔基体膜蛋白的靶向与滞留
Curr Opin Cell Biol. 1993 Aug;5(4):606-12. doi: 10.1016/0955-0674(93)90129-e.
10
Sorting of membrane proteins in the secretory pathway.分泌途径中膜蛋白的分选
Cell. 1993 Nov 19;75(4):603-5. doi: 10.1016/0092-8674(93)90479-a.

新鉴定出的酵母GRD基因是晚期高尔基体膜蛋白滞留所必需的。

The newly identified yeast GRD genes are required for retention of late-Golgi membrane proteins.

作者信息

Nothwehr S F, Bryant N J, Stevens T H

机构信息

Division of Biological Sciences, University of Missouri, Columbia 65211, USA.

出版信息

Mol Cell Biol. 1996 Jun;16(6):2700-7. doi: 10.1128/MCB.16.6.2700.

DOI:10.1128/MCB.16.6.2700
PMID:8649377
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC231260/
Abstract

Processing of A-ALP, a late-Golgi membrane protein constructed by fusing the cytosolic domain of dipeptidyl aminopeptidase A to the transmembrane and lumenal domains of alkaline phosphatase (ALP), serves as a convenient assay for loss of retention of late-Golgi membrane proteins in Saccharomyces cerevisiae. In this study, a large group of novel grd (for Golgi retention defective) yeast mutants, representing 18 complementation groups, were identified on the basis of their mislocalization of A-ALP to the vacuole, where it was proteolytically processed and thus became enzymatically activated. All of the grd mutants exhibited significant mislocalization of A-ALP, as measured by determining the kinetics of A-ALP processing and by analyzing its

摘要

A-ALP是一种晚期高尔基体膜蛋白，通过将二肽基氨基肽酶A的胞质结构域与碱性磷酸酶（ALP）的跨膜结构域和腔结构域融合构建而成。对A-ALP的加工过程可作为一种便捷的检测方法，用于检测酿酒酵母中晚期高尔基体膜蛋白保留功能的丧失。在本研究中，基于A-ALP在液泡中的错误定位（在液泡中它被蛋白水解加工并因此被酶激活），鉴定出一大组新的grd（高尔基体保留缺陷）酵母突变体，它们代表18个互补群。通过测定A-ALP加工的动力学并分析其……，所有grd突变体均表现出A-ALP的显著错误定位。