Csernansky J G, Bardgett M E, Sheline Y I, Morris J C, Olney J W
Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
Neurology. 1996 Jun;46(6):1715-20. doi: 10.1212/wnl.46.6.1715.
Researchers have proposed that increased release of excitatory amino acids (EAAs) is involved in the pathogenesis of dementia of the Alzheimer type (DAT), and CSF EAA concentrations have been measured to obtain evidence in support of this hypothesis. However, previous comparisons of CSF EAA concentrations in patients with DAT and in controls have yielded inconsistent results, perhaps because patient samples have been heterogeneous as to dementia severity. To determine whether there are changes in CSF concentrations of EAAs related to severity of illness in patients with DAT, we measured CSF concentrations of glutamate, aspartate, and taurine in 32 subjects with DAT, in whom we also assessed the severity of illness using clinical and neuropsychological measures, and 11 age-matched controls. The results suggested that increased CSF aspartate and glutamate concentrations, as well as decreased taurine concentrations, may occur in some persons with more advanced symptoms of DAT.
研究人员提出，兴奋性氨基酸（EAA）释放增加与阿尔茨海默型痴呆（DAT）的发病机制有关，并且已经测量了脑脊液中EAA的浓度以获取支持这一假设的证据。然而，先前对DAT患者和对照组脑脊液EAA浓度的比较结果并不一致，这可能是因为患者样本在痴呆严重程度方面存在异质性。为了确定DAT患者脑脊液中EAA浓度是否随疾病严重程度而变化，我们测量了32名DAT患者脑脊液中谷氨酸、天冬氨酸和牛磺酸的浓度，我们还使用临床和神经心理学测量方法评估了这些患者的疾病严重程度，并与11名年龄匹配的对照组进行了比较。结果表明，在一些症状较严重的DAT患者中，脑脊液中天冬氨酸和谷氨酸浓度可能会升高，而牛磺酸浓度可能会降低。
