Roca R P, Wigley F M, White B
The Bayview Medical Center, and Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Arthritis Rheum. 1996 Jun;39(6):1035-40. doi: 10.1002/art.1780390623.
To examine the prevalence and correlates of depressive symptoms among patients with systemic sclerosis (SSc; scleroderma).
Fifty-four outpatients with scleroderma were administered the Beck Depression Inventory, the Neuroticism-Extraversion-Openness Personality Inventory, the Health Assessment Questionnaire, and the Psychosocial Adjustment to Illness Scale. In addition, patients underwent a comprehensive clinical assessment, and pulmonary function tests were obtained.
Nearly half of the patients had mild depressive symptoms, and an additional 17% had symptoms in the moderate-to-severe range. Younger patients, those with digital ulceration, and those with more self-rate functional impairment had more depressive symptoms, but there were few other relationships between depressive symptoms and either demographic or physician-rated medical variables. In contrast, there were highly significant relationships between depression and aspects of personality, psychosocial adjustment to illness, and social support.
Depressive symptoms in patients with SSc are more strongly related to personality, self-rated disability, and adequacy of emotional support than to objective medical indices of illness severity. Depression in scleroderma is a debilitating comorbid condition that should be recognized and treated in its own right.
研究系统性硬化症（SSc；硬皮病）患者抑郁症状的患病率及其相关因素。
对54例硬皮病门诊患者进行了贝克抑郁量表、神经质-外向性-开放性人格量表、健康评估问卷和疾病心理社会适应量表的测评。此外，患者还接受了全面的临床评估，并进行了肺功能测试。
近一半患者有轻度抑郁症状，另有17%的患者症状处于中重度范围。年轻患者、有指端溃疡的患者以及自我评估功能损害较严重的患者有更多的抑郁症状，但抑郁症状与人口统计学或医生评估的医学变量之间几乎没有其他关联。相比之下，抑郁与人格、疾病心理社会适应及社会支持方面存在高度显著的关联。
SSc患者的抑郁症状与人格、自我评估的残疾程度及情感支持的充分性的关系比与疾病严重程度的客观医学指标的关系更为密切。硬皮病中的抑郁是一种使人衰弱的共病情况，应予以识别并进行独立治疗。
