血清幽门螺杆菌抗体滴度与肠化生程度的负相关关系。
Inverse relation of serum Helicobacter pylori antibody titres and extent of intestinal metaplasia.
作者信息
Osawa H, Inoue F, Yoshida Y
机构信息
Department of Internal Medicine, Nishiarita Kyoritsu Hospital, Japan.
出版信息
J Clin Pathol. 1996 Feb;49(2):112-5. doi: 10.1136/jcp.49.2.112.
AIMS
To clarify the relation between the serum titre of anti-Helicobacter pylori (H pylori) antibody and the extent of intestinal metaplasia of the gastric mucosa.
METHODS
The serum anti-H pylori IgG titres of 95 asymptomatic individuals (mean age 65 years) undergoing an annual health examination were measured and compared with the extent of intestinal metaplasia (absent, moderate, or extensive), determined by examination of multiple endoscopic mucosal biopsy specimens. Serum pepsinogen I (PGI) levels, as a marker for gastric atrophy, were also measured.
RESULTS
The prevalence of seropositivity for H pylori antibody was high (> 80%), regardless of the extent of metaplasia. However, there was a negative association between the extent of metaplasia and the anti-H pylori titre: 75% of the subjects in the group without metaplasia had high (3+) antibody levels, as did 43% with moderate, and 37% with extensive metaplasia (absent v extensive). The inverse relation between the titre and the extent of metaplasia was evident when examined in those with normal PGI (> 30 ng/ml), whereas no such relation was apparent in subjects with low PGI (< or = 30 ng/ml).
CONCLUSIONS
The anti-H pylori titre correlates inversely with the extent of intestinal metaplasia, particularly in subjects with less marked gastric atrophy.
目的
阐明血清抗幽门螺杆菌（H pylori）抗体滴度与胃黏膜肠化生程度之间的关系。
方法
检测95名接受年度健康检查的无症状个体（平均年龄65岁）的血清抗H pylori IgG滴度，并与通过多个内镜黏膜活检标本检查确定的肠化生程度（无、中度或广泛）进行比较。还测量了血清胃蛋白酶原I（PGI）水平，作为胃萎缩的标志物。
结果
无论化生程度如何，幽门螺杆菌抗体血清阳性率都很高（>80%）。然而，化生程度与抗幽门螺杆菌滴度之间存在负相关：无化生组中75%的受试者抗体水平高（3+），中度化生组为43%，广泛化生组为37%（无化生组与广泛化生组相比）。在PGI正常（>30 ng/ml）的受试者中检查时，滴度与化生程度之间的负相关很明显，而在PGI低（≤30 ng/ml）的受试者中没有这种关系。
结论
抗幽门螺杆菌滴度与肠化生程度呈负相关，尤其是在胃萎缩不太明显的受试者中。
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