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Brain-derived neurotrophic factor and neurotrophin-4/5 stimulate growth of axonal branches from regenerating retinal ganglion cells.脑源性神经营养因子和神经营养因子-4/5刺激再生视网膜神经节细胞轴突分支的生长。
J Neurosci. 1996 Jun 15;16(12):3887-94. doi: 10.1523/JNEUROSCI.16-12-03887.1996.
2
Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative in vivo study.轴突切断术及眼内注射神经营养因子4、神经营养因子3和脑源性神经营养因子对成年大鼠视网膜神经节细胞存活的影响。一项定量体内研究。
Invest Ophthalmol Vis Sci. 1996 Mar;37(4):489-500.
3
The outgrowth response of the axons of developing and regenerating rat retinal ganglion cells in vitro to neurotrophin treatment.发育中和再生中的大鼠视网膜神经节细胞轴突在体外对神经营养因子治疗的生长反应。
J Neurocytol. 2003 Nov;32(9):1055-75. doi: 10.1023/B:NEUR.0000021902.65233.8d.
4
Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells.眼外伤及给予脑源性神经营养因子对视网膜神经节细胞轴突切断后存活及再生的影响
Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1632-6. doi: 10.1073/pnas.91.5.1632.
5
Brain-derived neurotrophic factor differentially regulates retinal ganglion cell dendritic and axonal arborization in vivo.脑源性神经营养因子在体内对视网膜神经节细胞的树突和轴突分支有不同的调节作用。
J Neurosci. 1999 Nov 15;19(22):9928-38. doi: 10.1523/JNEUROSCI.19-22-09928.1999.
6
Neurotrophic factors increase axonal growth after spinal cord injury and transplantation in the adult rat.神经营养因子可促进成年大鼠脊髓损伤及移植后的轴突生长。
Exp Neurol. 1997 Dec;148(2):475-94. doi: 10.1006/exnr.1997.6705.
7
Local and target-derived brain-derived neurotrophic factor exert opposing effects on the dendritic arborization of retinal ganglion cells in vivo.局部和靶源性脑源性神经营养因子对体内视网膜神经节细胞的树突分支具有相反的作用。
J Neurosci. 2002 Sep 1;22(17):7639-49. doi: 10.1523/JNEUROSCI.22-17-07639.2002.
8
CNTF, not other trophic factors, promotes axonal regeneration of axotomized retinal ganglion cells in adult hamsters.睫状神经营养因子而非其他营养因子可促进成年仓鼠视网膜神经节细胞轴突切断后的轴突再生。
Invest Ophthalmol Vis Sci. 1999 Mar;40(3):760-6.
9
Neurturin enhances the survival of axotomized retinal ganglion cells in vivo: combined effects with glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor.神经营养因子增强体内视网膜节细胞轴突切断后的存活：与胶质细胞源性神经营养因子和脑源性神经营养因子的联合作用
Neuroscience. 2002;110(3):555-67. doi: 10.1016/s0306-4522(01)00557-7.
10
Intravitreal injections of neurotrophic factors and forskolin enhance survival and axonal regeneration of axotomized beta ganglion cells in cat retina.玻璃体内注射神经营养因子和福斯高林可提高猫视网膜中轴突切断的β神经节细胞的存活率并促进其轴突再生。
Neuroscience. 2003;116(3):733-42. doi: 10.1016/s0306-4522(02)00562-6.

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Glial cells modulate retinal cell survival in rotenone-induced neural degeneration.神经退行性变中神经胶质细胞对视网膜细胞存活的调节作用。
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BDNF: mRNA expression in urine cells of patients with chronic kidney disease and its role in kidney function.BDNF：慢性肾脏病患者尿细胞中的 mRNA 表达及其在肾功能中的作用。
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10
The Krüppel-Like Factor Gene Target Dusp14 Regulates Axon Growth and Regeneration.Krüppel 样因子基因靶标 Dusp14 调节轴突生长和再生。
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本文引用的文献

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Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase.神经生长因子（NGF）刺激的神经突生长的起始和维持需要磷酸肌醇3激酶的激活。
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Selective enhancement of axonal branching of cultured dentate gyrus neurons by neurotrophic factors.神经营养因子对培养的齿状回神经元轴突分支的选择性增强作用。
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Different forms of the neurotrophin receptor trkB mRNA predominate in rat retina and optic nerve.神经营养因子受体trkB mRNA的不同形式在大鼠视网膜和视神经中占主导地位。
J Neurobiol. 1993 Sep;24(9):1207-14. doi: 10.1002/neu.480240907.
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Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells.眼外伤及给予脑源性神经营养因子对视网膜神经节细胞轴突切断后存活及再生的影响
Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1632-6. doi: 10.1073/pnas.91.5.1632.
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Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats.轴突切断术会导致成年大鼠视网膜神经节细胞延迟死亡和凋亡。
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脑源性神经营养因子和神经营养因子-4/5刺激再生视网膜神经节细胞轴突分支的生长。

Brain-derived neurotrophic factor and neurotrophin-4/5 stimulate growth of axonal branches from regenerating retinal ganglion cells.

作者信息

Sawai H, Clarke D B, Kittlerova P, Bray G M, Aguayo A J

机构信息

Centre for Research in Neuroscience, Montréal General Hospital Research Institute, Québec, Canada.

出版信息

J Neurosci. 1996 Jun 15;16(12):3887-94. doi: 10.1523/JNEUROSCI.16-12-03887.1996.

DOI:10.1523/JNEUROSCI.16-12-03887.1996
PMID:8656282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6578616/
Abstract

To investigate the influences of growth factors on axonal regeneration in the mammalian CNS, we used intracellular tracers to quantitate the effects of brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-4/5, or NT-3 on individual retinal ganglion cell (RGC) axons in the retinas of adult rats after optic nerve transection. A single injection of BDNF or the prolonged administration of NT-4/5 by mini-pump increased axon branch median lengths by eightfold but had no effect on the number of branches formed by the RGC axons. NT-3 did not significantly influence axonal regrowth. These specific in vivo effects of BDNF and NT-4/5 on axonal regeneration from injured RGCs may be used to promote growth and expand the abnormally small terminal arbors observed when RGCs regrow into their CNS targets.

摘要

为研究生长因子对哺乳动物中枢神经系统轴突再生的影响，我们使用细胞内示踪剂来定量脑源性神经营养因子（BDNF）、神经营养素（NT）-4/5或NT-3对视神经横断后成年大鼠视网膜中单个视网膜神经节细胞（RGC）轴突的作用。单次注射BDNF或通过微型泵长期给予NT-4/5可使轴突分支的中位长度增加八倍，但对RGC轴突形成的分支数量没有影响。NT-3对轴突再生没有显著影响。BDNF和NT-4/5对受损RGC轴突再生的这些特定体内效应可用于促进生长，并扩大当RGC重新长入其CNS靶点时观察到的异常小的终末分支。