脑源性神经营养因子和神经营养因子-4/5刺激再生视网膜神经节细胞轴突分支的生长。
Brain-derived neurotrophic factor and neurotrophin-4/5 stimulate growth of axonal branches from regenerating retinal ganglion cells.
作者信息
Sawai H, Clarke D B, Kittlerova P, Bray G M, Aguayo A J
机构信息
Centre for Research in Neuroscience, Montréal General Hospital Research Institute, Québec, Canada.
出版信息
J Neurosci. 1996 Jun 15;16(12):3887-94. doi: 10.1523/JNEUROSCI.16-12-03887.1996.
Abstract
To investigate the influences of growth factors on axonal regeneration in the mammalian CNS, we used intracellular tracers to quantitate the effects of brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-4/5, or NT-3 on individual retinal ganglion cell (RGC) axons in the retinas of adult rats after optic nerve transection. A single injection of BDNF or the prolonged administration of NT-4/5 by mini-pump increased axon branch median lengths by eightfold but had no effect on the number of branches formed by the RGC axons. NT-3 did not significantly influence axonal regrowth. These specific in vivo effects of BDNF and NT-4/5 on axonal regeneration from injured RGCs may be used to promote growth and expand the abnormally small terminal arbors observed when RGCs regrow into their CNS targets.
摘要
为研究生长因子对哺乳动物中枢神经系统轴突再生的影响，我们使用细胞内示踪剂来定量脑源性神经营养因子（BDNF）、神经营养素（NT）-4/5或NT-3对视神经横断后成年大鼠视网膜中单个视网膜神经节细胞（RGC）轴突的作用。单次注射BDNF或通过微型泵长期给予NT-4/5可使轴突分支的中位长度增加八倍，但对RGC轴突形成的分支数量没有影响。NT-3对轴突再生没有显著影响。BDNF和NT-4/5对受损RGC轴突再生的这些特定体内效应可用于促进生长，并扩大当RGC重新长入其CNS靶点时观察到的异常小的终末分支。
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