Heo M Y, Jae L H, Jung S S, Au W W
College of Pharmacy, Kangweon National University, Chuncheon, South Korea.
Mutat Res. 1996 May 17;360(1):37-41. doi: 10.1016/s0165-1161(96)90235-6.
We investigated the suppressive effect of galangin on the induction of micronucleated reticulocytes (MNRETs) by mitomycin C (MMC) in mouse peripheral blood. When galangin was given to mice 24 h before the intraperitoneal injection of MMC (1 mg/kg), a more marked decrease in the frequency of MNRETs was observed than in mice with simultaneous and post-treatment of galangin. On the other hand, when galangin was given to mice for 7 consecutive days before MMC injection, galangin showed potent anticlastogenic effects, even at the lowest dose level of 0.1 mg/kg. Results from our in vivo studies indicate that galangin is capable of suppressing the clastogenic activity of the direct acting MMC. Together with our earlier observations, it appears that galangin is capable of protecting cells from the toxic effects of a variety of hazardous chemicals. Therefore, galangin may be an useful chemopreventive compound.
我们研究了高良姜素对丝裂霉素C（MMC）诱导小鼠外周血微核网织红细胞（MNRETs）的抑制作用。当在腹腔注射MMC（1 mg/kg）前24小时给小鼠给予高良姜素时，观察到MNRETs频率的下降比同时给予高良姜素和MMC后处理的小鼠更明显。另一方面，当在注射MMC前连续7天给小鼠给予高良姜素时，即使在最低剂量水平0.1 mg/kg，高良姜素也显示出强大的抗致断裂作用。我们体内研究的结果表明，高良姜素能够抑制直接作用的MMC的致断裂活性。结合我们早期的观察结果，似乎高良姜素能够保护细胞免受多种有害化学物质的毒性作用。因此，高良姜素可能是一种有用的化学预防化合物。
