Rutkowska-Sak L, Legatowicz-Koprowska M, Ryzko J, Socha J
Klinika Reumatologii Wieku Rozwojowego Instytutu Reumatologii w Warszawie.
Pediatr Pol. 1995 Mar;70(3):235-41.
Functional and morphological changes of the gastrointestinal system were assessed in patients suffering from juvenile chronic arthritis, juvenile systemic erythematosus and juvenile systemic scleroderma. The results of endoscopic investigation of the gastrointestinal tract showed inflammatory changes and cardiac and pylorus atony. Ultrasonography results suggested hepatic and pancreatic inflammatory changes, steatosis and/or amyloidosis. The above-mentioned changes were confirmed by morphological investigation (biopsy and/or autopsy). The results of the capacity tests performed in JCA (systemic form) patients revealed an impairment of liver detoxication function, and pancreas and bowel functional capacity as well. Additionally, intolerance against lactose, casein and alpha- and beta-lactoglobulin was found in most of the patients. Some symptoms of malnutrition were observed in all of them. Such factors as underlying disease severity, adverse drug effects, environmental factors (infections, nutrition) were taken into consideration as probable causes of the gastrointestinal system damage.
对患有青少年慢性关节炎、青少年系统性红斑狼疮和青少年系统性硬皮病的患者的胃肠系统功能和形态变化进行了评估。胃肠道内镜检查结果显示有炎症变化以及贲门和幽门无张力。超声检查结果提示肝脏和胰腺有炎症变化、脂肪变性和/或淀粉样变性。上述变化通过形态学检查（活检和/或尸检）得到证实。对青少年慢性关节炎（全身型）患者进行的能力测试结果显示肝脏解毒功能以及胰腺和肠道功能能力受损。此外，大多数患者存在对乳糖、酪蛋白以及α-和β-乳球蛋白的不耐受。在所有患者中均观察到一些营养不良症状。诸如潜在疾病严重程度、药物不良反应、环境因素（感染、营养）等因素被视为胃肠系统损害的可能原因。
