Wu A W, Coleson L C, Holbrook J, Jabs D A
Department of Health Policy and Management, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Md., USA.
Arch Ophthalmol. 1996 Jul;114(7):841-7. doi: 10.1001/archopht.1996.01100140055008.
To develop and test a brief questionnaire designed to assess visual symptoms, visual function in daily activities, and impact of treatment administration in patients with cytomegalovirus retinitis related to acquired immunodeficiency syndrome.
Observational cross-sectional study. Patients were recruited in June and July 1992.
Seven university-based sites participating in the Studies of Ocular Complications of AIDS.
Twenty-six subjects enrolled in a randomized trial that compared foscarnet and ganciclovir for the treatment of cytomegalovirus retinitis. MAIN OUTCOME MEASURES AND ANALYSIS: Distributions of scores, reliability, and validity of newly developed scales to assess visual function, visual symptoms, and global vision. Spearman rank correlations with 95% confidence intervals were used to test hypothesized relationships between scale scores, visual acuity, visual field, and findings from visual examination.
The final 18-item self-administered questionnaire required 5 minutes to complete. The new scales had high internal consistency (Cronbach alpha = .81 to .94). As hypothesized, patient-reported vision scores decreased with greater abnormalities found on ophthalmologic examination. Visual symptoms were most strongly related to findings in the worse eye. Visual function and global vision scores were moderately correlated with findings from visual testing and examination, and less strongly related to general health perceptions. Patients reported considerable impairment: 42% reported blurred vision; 40%, difficulty reading; 44%, difficulty driving; and 40%, that treatment interfered with social activities; 50% reported substantial trouble with their vision.
The brief questionnaire developed to assess patient-reported visual function in cytomegalovirus retinitis appears reliable and valid as a measure of performance of vision-related activities, visual symptoms, and the impact of treatment administration. Further research is needed to test its utility as an outcome measure in longitudinal studies of cytomegalovirus retinitis.
开发并测试一份简短问卷，用于评估与获得性免疫缺陷综合征相关的巨细胞病毒性视网膜炎患者的视觉症状、日常活动中的视觉功能以及治疗给药的影响。
观察性横断面研究。患者于1992年6月和7月招募。
七个参与艾滋病眼部并发症研究的大学附属医院。
26名受试者参加了一项随机试验，该试验比较了膦甲酸钠和更昔洛韦治疗巨细胞病毒性视网膜炎的效果。主要观察指标和分析：新开发的用于评估视觉功能、视觉症状和整体视力的量表的得分分布、信度和效度。使用Spearman等级相关及95%置信区间来检验量表得分、视力、视野和视力检查结果之间的假设关系。
最终的18项自填式问卷需要5分钟完成。新量表具有较高的内部一致性（Cronbach α系数=0.81至0.94）。正如所假设的，眼科检查发现的异常越严重，患者报告的视力得分越低。视觉症状与较差眼睛的检查结果相关性最强。视觉功能和整体视力得分与视力测试和检查结果中度相关，与一般健康认知的相关性较弱。患者报告了相当大的功能损害：42%报告视力模糊；40%报告阅读困难；44%报告驾驶困难；40%报告治疗干扰社交活动；50%报告视力有严重问题。
为评估巨细胞病毒性视网膜炎患者报告的视觉功能而开发的简短问卷，作为衡量与视力相关活动表现、视觉症状和治疗给药影响的指标，似乎可靠且有效。需要进一步研究以测试其作为巨细胞病毒性视网膜炎纵向研究结局指标的效用。
