• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

一种编码人β2整合素α亚基的新基因的克隆与染色体定位。

Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit.

作者信息

Wong D A, Davis E M, LeBeau M, Springer T A

机构信息

Center For Blood Research, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Gene. 1996 Jun 1;171(2):291-4. doi: 10.1016/0378-1119(95)00869-1.

DOI:10.1016/0378-1119(95)00869-1
PMID:8666289
Abstract

We isolated a partial genomic clone encoding ITGAD, a novel beta 2-integrin alpha subunit. The ITGAD gene is highly homologous to the three previously known alpha subunit-encoding genes, that compose the beta 2 integrin family, in deduced amino acid sequence, intron/exon structure and mapping location (chromosome 16p11).

摘要

我们分离出了一个编码ITGAD(一种新型β2整合素α亚基)的部分基因组克隆。ITGAD基因在推导的氨基酸序列、内含子/外显子结构和定位位置(染色体16p11)方面,与之前已知的构成β2整合素家族的三个α亚基编码基因高度同源。

相似文献

1
Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit.一种编码人β2整合素α亚基的新基因的克隆与染色体定位。
Gene. 1996 Jun 1;171(2):291-4. doi: 10.1016/0378-1119(95)00869-1.
2
Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11).新型人类整合素α11亚基(ITGA11)的克隆、序列分析及染色体定位
Genomics. 1999 Sep 1;60(2):179-87. doi: 10.1006/geno.1999.5909.
3
cDNA cloning and chromosomal localization of human alpha(11) integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues.人α(11)整合素的cDNA克隆及染色体定位。一种存在于肌肉组织中的与β(1)相关的整合素α链,含I结构域且能结合胶原蛋白。
J Biol Chem. 1999 Sep 3;274(36):25735-42. doi: 10.1074/jbc.274.36.25735.
4
Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes.人α6整合素亚基的分子克隆。α6 mRNA的可变剪接以及α6和β4基因的染色体定位。
Eur J Biochem. 1991 Jul 15;199(2):425-33. doi: 10.1111/j.1432-1033.1991.tb16140.x.
5
Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution.人黏膜淋巴细胞整合素αE亚基的分子克隆。异常结构与受限的RNA分布。
J Biol Chem. 1994 Feb 25;269(8):6016-25.
6
Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle.整合素α9亚基的序列和组织分布,β1的一种新型伴侣,广泛分布于上皮和肌肉中。
J Cell Biol. 1993 Dec;123(5):1289-97. doi: 10.1083/jcb.123.5.1289.
7
The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization.
Cytogenet Cell Genet. 1999;87(3-4):238-44. doi: 10.1159/000015434.
8
Cloning and sequence of the cDNA encoding the rat oligodendrocyte integrin beta 1 subunit.大鼠少突胶质细胞整合素β1亚基编码cDNA的克隆与序列分析
Gene. 1995 Jun 9;158(2):287-90. doi: 10.1016/0378-1119(94)00911-b.
9
The integrin alpha v gene: identification and characterization of the promoter region.整合素αv基因:启动子区域的鉴定与特征分析
Biochim Biophys Acta. 1994 Sep 13;1219(1):228-32. doi: 10.1016/0167-4781(94)90278-x.
10
Molecular cloning of the alpha subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha subunits of integrins.人和豚鼠白细胞黏附糖蛋白Mo1 α亚基的分子克隆:染色体定位及与整合素α亚基的同源性
Proc Natl Acad Sci U S A. 1988 Apr;85(8):2776-80. doi: 10.1073/pnas.85.8.2776.

引用本文的文献

1
Novel Mutation Is Responsible for a Severe Form of Leucocyte Adhesion Deficiency Type 1.新型突变导致严重的白细胞黏附缺陷症 1 型。
Biomed Res Int. 2022 Mar 3;2022:1141280. doi: 10.1155/2022/1141280. eCollection 2022.
2
β2 Integrin CD11d/CD18: From Expression to an Emerging Role in Staged Leukocyte Migration.β2 整合素 CD11d/CD18:从表达到白细胞迁移级联反应中新兴作用。
Front Immunol. 2021 Nov 8;12:775447. doi: 10.3389/fimmu.2021.775447. eCollection 2021.
3
Expression Profile of the Integrin Receptor Subunits in the Guinea Pig Sclera.
豚鼠巩膜中整合素受体亚基的表达谱
Curr Eye Res. 2017 Jun;42(6):857-863. doi: 10.1080/02713683.2016.1262045. Epub 2017 Jan 17.
4
Integrin αDβ2 (CD11d/CD18) is expressed by human circulating and tissue myeloid leukocytes and mediates inflammatory signaling.整合素αDβ2(CD11d/CD18)在人类循环和组织髓系白细胞中表达,并介导炎症信号传导。
PLoS One. 2014 Nov 21;9(11):e112770. doi: 10.1371/journal.pone.0112770. eCollection 2014.
5
beta2-integrins in demyelinating disease: not adhering to the paradigm.脱髓鞘疾病中的β2 整合素:不遵循范式。
J Leukoc Biol. 2010 Mar;87(3):397-403. doi: 10.1189/jlb.1009654. Epub 2009 Dec 9.
6
Two Novel Frame Shift, Recurrent and De Novo Mutations in the ITGB2 (CD18) Gene Causing Leukocyte Adhesion Deficiency in a Highly Inbred North African Population.ITGB2(CD18)基因中的两种新型移码、复发性和新生突变导致一个高度近亲繁殖的北非人群出现白细胞黏附缺陷。
J Biomed Biotechnol. 2001;1(3):114-121. doi: 10.1155/S1110724301000250.