Croxson S C, Jagger C
Department of Geriatrics, Bristol General Hospital.
Age Ageing. 1995 Sep;24(5):421-4. doi: 10.1093/ageing/24.5.421.
To ascertain whether diabetes in elderly people is associated with cognitive impairment, we offered all residents of Melton Mowbray aged 75, 80 and 85 years both a modified glucose tolerance test (1985 WHO criteria) and Folstein mental state examination (MMSE, 23/24 cut-off). Analysis of the results, stratified by age, revealed that subjects with known diabetes were more likely than normal subjects to have low MMSE [odds ratio 3.30 (95% CI 1.3 to 8.5)], whilst newly found diabetic subjects were less likely to have low MMSE [odds ratio 5(-14) (95% CI 9(-25) to 0.003)]. The difference between known and newly found diabetic subjects might relate to duration of diabetes. The increased frequency of cognitive impairment in known diabetic subjects may be pertinent to the safe use of hypoglycaemic agents.
为确定老年人糖尿病是否与认知障碍有关，我们对梅尔顿莫布雷所有75岁、80岁和85岁的居民进行了改良糖耐量试验（1985年世界卫生组织标准）和福斯廷简易精神状态检查表（MMSE，临界值为23/24）。按年龄分层的结果分析显示，已知糖尿病患者比正常受试者更有可能出现低MMSE评分[比值比3.30（95%置信区间1.3至8.5）]，而新发现的糖尿病患者出现低MMSE评分的可能性较小[比值比5（-14）（95%置信区间9（-25）至0.003）]。已知糖尿病患者和新发现糖尿病患者之间的差异可能与糖尿病病程有关。已知糖尿病患者认知障碍频率的增加可能与安全使用降糖药物有关。
