Kluger M T, Owen H, Plummer J L, McLean C
Flinders Medical Centre, Adelaide, South Australia.
Anaesth Intensive Care. 1995 Dec;23(6):687-90. doi: 10.1177/0310057X9502300605.
The aim of this study was to determine whether fasting gastric volumes could be reduced by preoperative administration of cisapride. One hundred and twenty-one patients undergoing elective general anaesthesia were randomly allocated to receive either cisapride 20 mg plus diazepam 10 mg or placebo tablets plus diazepam 10 mg, two hours prior to induction. Immediately following induction blind gastric aspiration was performed using a 16Fr multiorificed orogastric tube. Gastric volume, pH, and cisapride blood concentration were measured at this time. Gastric volumes were significantly smaller in the cisapride group, 20.5 (SD 22.2) ml compared to placebo 28.2 (SD 26.0) ml but there was no significant difference with respect to pH. Some patients in both groups had large gastric volumes despite fasting. No significant adverse effects were noted with cisapride.
本研究的目的是确定术前给予西沙必利是否可以减少空腹时的胃容量。121例接受择期全身麻醉的患者被随机分配，在诱导前两小时接受20毫克西沙必利加10毫克地西泮或安慰剂加10毫克地西泮。诱导后立即使用16Fr多孔口胃管进行盲法胃抽吸。此时测量胃容量、pH值和西沙必利血药浓度。西沙必利组的胃容量明显较小，为20.5（标准差22.2）毫升，而安慰剂组为28.2（标准差26.0）毫升，但pH值无显著差异。两组中一些患者尽管禁食，但胃容量仍很大。未观察到西沙必利有明显的不良反应。
