Gajewska J, Szczypka M, Laskowska-Klita T, Perek D
Zakład Biochemii Instytutu Matki i Dziecka w Warszawie.
Pediatr Pol. 1995 Nov;70(11):907-10.
In this study we examined selected elements of the antioxidant defence system in the plasma of children with the most common solid tumors (nephroblastoma, neuroblastoma, rhabdomyosarcoma, osteosarcoma). We observed a significant increase of plasma antioxidant activity (AOA) in the majority of the examined children. This factor changed during clinical treatment, i.e. induction of chemotherapy, surgery and/or radiotherapy and during maintenance chemotherapy. We conclude that the elevated plasma antioxidant activity in children with malignancy may be due to the higher concentration of ceruloplasmin in affected children than in their healthy counterparts.
在本研究中，我们检测了患有最常见实体瘤（肾母细胞瘤、神经母细胞瘤、横纹肌肉瘤、骨肉瘤）儿童血浆中抗氧化防御系统的特定成分。我们观察到，大多数接受检测的儿童血浆抗氧化活性（AOA）显著增加。这一因素在临床治疗期间发生变化，即化疗诱导期、手术和/或放疗期间以及维持化疗期间。我们得出结论，恶性肿瘤患儿血浆抗氧化活性升高可能是由于患病儿童体内铜蓝蛋白浓度高于健康儿童。
