Schoen R E, Evans R W, Sankey S S, Weissfeld J L, Kuller L
Division of Gastroenterology, University of Pittsburgh, PA, USA.
Int J Obes Relat Metab Disord. 1996 Apr;20(4):346-52.
To determine whether intra-abdominal adipose tissue differs from subcutaneous adipose tissue in fatty acid content.
Cross-sectional study of patients undergoing exploratory laparotomy, with adipose tissue sampling from subcutaneous, omental, mesenteric and retroperitoneal sites.
Nineteen subjects, 8 men and 11 women, with a mean age of 64 (range 39-80), mean weight 78.9 kg (range 51-157) and mean body mass index of 27.5 (range 19.2-51.4). Fourteen of the 19 were undergoing surgery for colorectal cancer.
Fatty acid content was assessed by gas chromatography and was compared between sites and between patients using general linear modeling. Spearman correlation coefficients were used to assess the association between subcutaneous and visceral adipose tissue.
For each of 17 fatty acids analyzed, there was a statistically significant difference in mean fatty acid values across individuals (p < 0.001). For seven of the fatty acids, there was a borderline or significant difference in mean fatty acid values across site, but there was no consistent pattern for one site differing from the others. Subcutaneous adipose tissue fatty acid content was highly correlated to visceral adipose tissue for saturated, unsaturated and trans fatty acids (p < 0.05 for 13 of 17 fatty acids). Variability across individuals was much greater than across site. The total explained variability (R2) for each fatty acid ranged between 49 and 93%, with the vast majority contributed by differences between individuals. CONCLUSION. Fatty acid content of subcutaneous abdominal adipose tissue is a good approximation of visceral adipose tissue. Because variability in fatty acid content is much larger between individuals than within a single individual across sites, subcutaneous abdominal adipose tissue fatty acid content can be used as a distinguishing characteristic among human populations.
确定腹部内脏脂肪组织与皮下脂肪组织在脂肪酸含量上是否存在差异。
对接受剖腹探查术的患者进行横断面研究，从皮下、网膜、肠系膜和腹膜后部位采集脂肪组织样本。
19名受试者，8名男性和11名女性，平均年龄64岁（范围39 - 80岁），平均体重78.9千克（范围51 - 157千克），平均体重指数27.5（范围19.2 - 51.4）。19名受试者中有14名因结直肠癌接受手术。
通过气相色谱法评估脂肪酸含量，并使用一般线性模型在不同部位和患者之间进行比较。采用Spearman相关系数评估皮下脂肪组织与内脏脂肪组织之间的关联。
对于所分析的17种脂肪酸中的每一种，个体间平均脂肪酸值存在统计学显著差异（p < 0.001）。对于其中7种脂肪酸，不同部位间平均脂肪酸值存在临界或显著差异，但没有一个部位与其他部位存在一致的差异模式。皮下脂肪组织的饱和、不饱和及反式脂肪酸含量与内脏脂肪组织高度相关（17种脂肪酸中有13种p < 0.05）。个体间的变异性远大于不同部位间的变异性。每种脂肪酸的总解释变异性（R2）在49%至93%之间，绝大多数由个体差异导致。
腹部皮下脂肪组织的脂肪酸含量可很好地代表内脏脂肪组织。由于脂肪酸含量在个体间的变异性远大于同一个体内不同部位间的变异性，腹部皮下脂肪组织的脂肪酸含量可作为人群间的一个区别特征。
