Rothe M J, Grant-Kels J M
Department of Medicine, University of Connecticut Health Center, Farmington 06030, USA.
J Am Acad Dermatol. 1996 Jul;35(1):1-13; quiz 14-6. doi: 10.1016/S0190-9622(96)90486-7.
This review focuses on recent literature regarding the following clinical features of atopic dermatitis (AD); diagnostic criteria, epidemiology and genetics, provocative factors, predictors of disease development and markers of disease severity, therapy, and prognosis. For example, the frequency of AD appears to be increasing, perhaps in response to provocative factors such as food allergens and house dust mites. Determination of reliable markers for disease development may identify susceptible newborns and facilitate avoidance of relevant triggers. Immunomodulating therapy holds promise in the treatment of refractory AD, and new investigation has led to refinements in conventional modalities such as antihistamines and phototherapy.
本综述聚焦于近期有关特应性皮炎（AD）以下临床特征的文献：诊断标准、流行病学与遗传学、诱发因素、疾病发展的预测因素及疾病严重程度标志物、治疗方法及预后。例如，AD的发病率似乎在上升，这可能是对食物过敏原和屋尘螨等诱发因素的反应。确定疾病发展的可靠标志物可能会识别出易感新生儿，并有助于避免相关触发因素。免疫调节疗法在难治性AD的治疗中具有前景，新的研究已使抗组胺药和光疗等传统治疗方式得到改进。
