van Vugt J M, van Zalen-Sprock R M, Kostense P J
Department of Obstetrics and Gynecology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
Radiology. 1996 Aug;200(2):537-40. doi: 10.1148/radiology.200.2.8685353.
To investigate the importance of nuchal translucencies in the first trimester of pregnancy as an ultrasonographic marker for fetal chromosome abnormalities.
One hundred two first-trimester fetuses with a nuchal translucency of 3 mm or more were karyotyped. Multiple logistic regression analysis was performed to estimate the risk of fetal chromosomal abnormalities related to nuchal translucencies.
Fifty-five (54%) of the fetuses had a normal karyotype. Forty-seven (46%) had an abnormal karyotype. The risk of chromosome abnormality was strongly increased in fetuses with a septated nuchal translucency compared with fetuses with a nonseptated nuchal translucency.
First-trimester nuchal translucency is an important ultrasonographic marker for chromosomal abnormalities in the fetus. The presence of a normal karyotype in a fetus is a strong indication that detailed ultrasonographic examination for associated anomalies should be undertaken.
探讨孕早期颈部半透明带作为胎儿染色体异常超声标志物的重要性。
对102例孕早期颈部半透明带厚度达3毫米或以上的胎儿进行核型分析。采用多因素logistic回归分析评估与颈部半透明带相关的胎儿染色体异常风险。
55例（54%）胎儿核型正常，47例（46%）胎儿核型异常。与无分隔的颈部半透明带胎儿相比，有分隔的颈部半透明带胎儿染色体异常风险显著增加。
孕早期颈部半透明带是胎儿染色体异常的重要超声标志物。胎儿核型正常强烈提示应进行详细的超声检查以排查相关异常。
