Nakashima K, Yamashita T, Kashiwagi S, Nakayama N, Kitahara T, Ito H
Department of Neurosurgery, Yamaguchi University School of Medicine, Japan.
Acta Neurol Scand Suppl. 1996;166:96-8. doi: 10.1111/j.1600-0404.1996.tb00561.x.
The effects of sodium bicarbonate on cerebral blood flow (CBF) and intracellular pH were studied in five normal volunteers. CBF and intracellular pH were measured by stable xenon computed tomography and phosphorus-31 magnetic resonance spectroscopy (31P-MRS) respectively. Each patient received 7% sodium bicarbonate (3.5 ml/kg body weight) infused intravenously for 15 minutes. Before and after this injection, CBF intracellular pH and physiological parameters were measured. CBF and PaCO2 were significantly increased. On the other hand, hematocrit and intracellular pH were decreased. These result suggests that three factors are thought to contribute to increase CBF during administration of sodium bicarbonate in humans: 1) arterial dilatation in response to carbon dioxide 2) an decrease of hematocrit 3) intracellular acidosis.
在五名正常志愿者中研究了碳酸氢钠对脑血流量（CBF）和细胞内pH值的影响。分别通过稳定氙计算机断层扫描和磷-31磁共振波谱（31P-MRS）测量CBF和细胞内pH值。每位患者静脉输注7%碳酸氢钠（3.5 ml/kg体重）15分钟。在此次注射前后，测量CBF、细胞内pH值和生理参数。CBF和动脉血二氧化碳分压（PaCO2）显著升高。另一方面，血细胞比容和细胞内pH值降低。这些结果表明，在人体使用碳酸氢钠期间，有三个因素被认为有助于增加CBF：1）对二氧化碳的动脉扩张反应；2）血细胞比容降低；3）细胞内酸中毒。
