Roque L, Oliveira P, Martins C, Carvalho C, Serpa A, Soares J
CIPM-Portuguese Cancer Institute, Lisbon, Portugal.
Cancer Genet Cytogenet. 1996 Jul 1;89(1):34-7. doi: 10.1016/0165-4608(95)00309-6.
Short-term cultures from an alveolar adenoma of the lung were cytogenetically examined. Of the 54 metaphases studied, 44 were characterized by an apparently normal karyotype and 10 showed a pseudodiploid karyotype: 46,XX,add(16)(q24). Fluorescence in situ hybridization studies permitted identification of the add(16)(q24) as a der(16)t(10;16)(q23;q24). This is the first report of a chromosomal aberration in an alveolar adenoma of the lung.
对来自肺肺泡腺瘤的短期培养物进行了细胞遗传学检查。在所研究的54个中期相中，44个具有明显正常的核型，10个显示假二倍体核型：46,XX,add(16)(q24)。荧光原位杂交研究确定add(16)(q24)为der(16)t(10;16)(q23;q24)。这是关于肺肺泡腺瘤染色体畸变的首次报道。
