Orihata M, Sarna S K
Department of Surgery, Medical College of Wisconsin and Zablocki VA Medical Center, Milwaukee 53295, USA.
Dig Dis Sci. 1996 Jul;41(7):1303-9. doi: 10.1007/BF02088551.
The effect of nitric oxide (NO) synthase inhibition on the gastric emptying of nutrient and nonnutrient meals was investigated in nine dogs. The inhibition of NO synthase delayed the gastric emptying time of both nutrient and nonnutrient meals, but the percentage delay of nutrient meals was significantly greater than that of nonnutrient meals. The inhibition of NO synthase during the emptying of nonnutrient meals enhanced mainly the amplitude of antral, pyloric, and distal duodenal contractions. However, NO synthase inhibition during the emptying of nutrient meals stimulated several spatial and temporal parameters of gastropyloroduodenal contractions. We conclude that NO is one of the neurotransmitters of intestinal feedback that regulates the gastric emptying of both nutrient and nonnutrient meals. The nature and intensity of intestinal feedback by the stimulation of both chemo- and mechanoreceptors by nutrient meals is different from that by the stimulation of mechanoreceptors only by the nonnutrient meals.
在9只狗身上研究了一氧化氮（NO）合酶抑制对营养性和非营养性食物胃排空的影响。抑制NO合酶会延迟营养性和非营养性食物的胃排空时间，但营养性食物的延迟百分比显著高于非营养性食物。在非营养性食物排空期间抑制NO合酶主要增强了胃窦、幽门和十二指肠远端收缩的幅度。然而，在营养性食物排空期间抑制NO合酶会刺激胃幽门十二指肠收缩的几个空间和时间参数。我们得出结论，NO是调节营养性和非营养性食物胃排空的肠道反馈神经递质之一。营养性食物通过刺激化学感受器和机械感受器产生的肠道反馈的性质和强度与仅由非营养性食物刺激机械感受器产生的肠道反馈不同。
