L-735,334, a novel sesquiterpenoid potassium channel-agonist from Trichoderma virens.
作者信息
Lee S H, Hensens O D, Helms G L, Liesch J M, Zink D L, Giacobbe R A, Bills G F, Stevens-Miles S, Garcia M L, Schmalhofer W A
机构信息
Department of Natural Products Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065-0900, USA.
出版信息
J Nat Prod. 1995 Dec;58(12):1822-8. doi: 10.1021/np50126a004.
A novel oleic acid ester of the carotane sesquiterpene 14-hydroxy CAF-603 was isolated from Trichoderma virens grown in a solid brown rice-based medium, a solid millet-based medium, or a mannitol-based liquid medium. Its structure was determined on the basis of ms and nmr analysis. It retains distinct biological activity on the high conductance calcium-activated potassium channel, unlike its analogues 14-hydroxy CAF-603, CAF-603 3-oleate, or CAF-603 3-linoleate.
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