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苦味叶下珠素可保护大鼠免受酒精诱导的慢性肝毒性。

Picroliv protects against alcohol-induced chronic hepatotoxicity in rats.

作者信息

Rastogi R, Saksena S, Garg N K, Kapoor N K, Agarwal D P, Dhawan B N

机构信息

Biochemistry Division, C.D.R.I., Lucknow, India.

出版信息

Planta Med. 1996 Jun;62(3):283-5. doi: 10.1055/s-2006-957882.

DOI:10.1055/s-2006-957882
PMID:8693047
Abstract

Daily administration of ethyl alcohol (3.76 g/kg, p.o.) for 45 days resulted in significant changes in several biochemical parameters of the liver and serum of albino rats. After exposure to alcohol for 30 days when Picroliv (12 mg/kg, p.o.), an iridoid glycoside fraction of Picrorhiza kurroa, was administered for 15 days along with alcohol, the degree of change in most of the parameters was reduced.

摘要

对白化大鼠每日经口给予乙醇(3.76克/千克),持续45天,导致其肝脏和血清的若干生化参数发生显著变化。在给予酒精30天后,同时给予胡黄连的环烯醚萜苷部分苦味叶下珠素(12毫克/千克,经口),持续15天,大多数参数的变化程度降低。

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1
Picroliv protects against alcohol-induced chronic hepatotoxicity in rats.苦味叶下珠素可保护大鼠免受酒精诱导的慢性肝毒性。
Planta Med. 1996 Jun;62(3):283-5. doi: 10.1055/s-2006-957882.
2
Ex vivo and in vivo investigations of picroliv from Picrorhiza kurroa in an alcohol intoxication model in rats.
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Inhibition of N-nitrosodiethylamine-induced hepatocarcinogenesis by Picroliv.苦味叶下珠对N-亚硝基二乙胺诱导的肝癌发生的抑制作用。
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Therapeutic efficacy of Picroliv in chronic cadmium toxicity.苦味叶下珠对慢性镉中毒的治疗效果。
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Evaluation of hepatoprotective activity of picroliv (from Picrorhiza kurroa) in Mastomys natalensis infected with Plasmodium berghei.苦味叶下珠(来自胡黄连)对感染伯氏疟原虫的南非多乳鼠的肝脏保护活性评估。
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Hepatocurative effect of picroliv and silymarin against aflatoxin B1 induced hepatotoxicity in rats.
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Protective activity of picroliv on hepatic amoebiasis associated with carbon tetrachloride toxicity.苦味叶下珠素对与四氯化碳毒性相关的肝脏阿米巴病的保护作用。
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Picroliv protects against monocrotaline-induced hepatic damage in rats.苦味叶下珠素可保护大鼠免受野百合碱诱导的肝损伤。
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Anticholestatic effect of picroliv, active hepatoprotective principle of Picrorhiza kurrooa, against carbon tetrachloride induced cholestasis.
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Effect of Picroliv on cadmium induced testicular damage in rat.苦味叶下珠对镉诱导的大鼠睾丸损伤的影响。
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