Kasturi K, Hannoun C
Ann Microbiol (Paris). 1977 Jan;128A(1):97-117.
IgA was found to be the predominant immunoglobulin in the bronchoalveolar secretions of rabbits. Significant quantities of IgG antibodies were also present in these secretions after intratracheal immunization with live influenza virus, but IgA/IgG ratios in the secretions were always higher than in corresponding sera, whether the rabbits were immunized or not. The relative excretion coefficients of IgA in these secretions were also found to be higher. In vitro culture of broncho-alveolar wash cells showed active synthesis of all the three major immunoglobulins with IgG as the predominant one. Immunization with live influenza virus induced a higher and more persistant antibody response in the respiratory secretions than the inactivated virus. A rapid and more intense production of IgA and IgG antibodies in these secretions after intratracheal booster antigen strongly suggests the presence of immunological memory in the secretory immune system of the respiratory tract. The role of secretory antiviral antibodies in protection against respiratory infections is also discussed.
已发现IgA是兔支气管肺泡分泌物中的主要免疫球蛋白。在用活流感病毒进行气管内免疫后，这些分泌物中也存在大量IgG抗体，但无论兔是否免疫，分泌物中的IgA/IgG比值总是高于相应血清中的比值。还发现这些分泌物中IgA的相对排泄系数更高。支气管肺泡灌洗细胞的体外培养显示，所有三种主要免疫球蛋白均有活跃合成，其中以IgG为主。与灭活病毒相比，用活流感病毒免疫在呼吸道分泌物中诱导出更高且更持久的抗体反应。气管内加强抗原后，这些分泌物中IgA和IgG抗体快速且更强烈地产生，这有力地表明呼吸道分泌免疫系统中存在免疫记忆。还讨论了分泌型抗病毒抗体在预防呼吸道感染中的作用。
