白细胞介素-10可保护新生小鼠免受B族链球菌致死性感染。
Interleukin-10 protects neonatal mice from lethal group B streptococcal infection.
作者信息
Cusumano V, Genovese F, Mancuso G, Carbone M, Fera M T, Teti G
机构信息
Istituto di Microbiologia, Facolta di Medicina e Chirurgia, Universita degli Studi di Messina, Italy.
出版信息
Infect Immun. 1996 Jul;64(7):2850-2. doi: 10.1128/iai.64.7.2850-2852.1996.
Abstract
We investigated the role of interleukin-10 (IL-10) in a neonatal mouse model of lethal group B streptococci (GBS) sepsis. Plasma IL-10 levels significantly increased at 24 and 48 h after GBS inoculation. Neutralization of IL-10 with specific antibodies had no effect on lethality. Administration of recombinant IL-10 at 20 or 4 h before challenge, but not at later times, resulted in decreased tumor necrosis factor alpha levels and improved survival. IL-10 could be potentially useful for the treatment of GBS sepsis.
摘要
我们在致死性B族链球菌（GBS）败血症的新生小鼠模型中研究了白细胞介素-10（IL-10）的作用。接种GBS后24小时和48小时，血浆IL-10水平显著升高。用特异性抗体中和IL-10对致死率没有影响。在攻击前20小时或4小时给予重组IL-10，但在更晚的时间给予则无效，这导致肿瘤坏死因子α水平降低并提高了生存率。IL-10可能对GBS败血症的治疗有用。
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本文引用的文献
1
Interleukin 10 protects mice from lethal endotoxemia.白细胞介素10可保护小鼠免受致死性内毒素血症的侵害。
J Exp Med. 1993 Apr 1;177(4):1205-8. doi: 10.1084/jem.177.4.1205.
2
Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia.白细胞介素10可减少肿瘤坏死因子的释放，并预防实验性内毒素血症中的致死情况。
J Exp Med. 1993 Feb 1;177(2):547-50. doi: 10.1084/jem.177.2.547.
3
Cytokine appearance and effects of anti-tumor necrosis factor alpha antibodies in a neonatal rat model of group B streptococcal infection.B族链球菌感染新生大鼠模型中细胞因子的出现及抗肿瘤坏死因子α抗体的作用
Infect Immun. 1993 Jan;61(1):227-35. doi: 10.1128/iai.61.1.227-235.1993.
4
Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock.白细胞介素10可保护小鼠免受葡萄球菌肠毒素B诱导的致死性休克。
Infect Immun. 1993 Nov;61(11):4937-9. doi: 10.1128/iai.61.11.4937-4939.1993.
5
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Annu Rev Immunol. 1993;11:165-90. doi: 10.1146/annurev.iy.11.040193.001121.
6
Interleukin 10 production correlates with pathology in human Leishmania donovani infections.白细胞介素10的产生与人类杜氏利什曼原虫感染中的病理学相关。
J Clin Invest. 1993 Jul;92(1):324-9. doi: 10.1172/JCI116570.
7
The cooperative effects of TNF-alpha and IFN-gamma are determining factors in the ability of IL-10 to protect mice from lethal endotoxemia.肿瘤坏死因子-α（TNF-α）和γ干扰素（IFN-γ）的协同作用是白细胞介素-10（IL-10）保护小鼠免受致死性内毒素血症影响的能力的决定因素。
J Leukoc Biol. 1994 Jun;55(6):711-8. doi: 10.1002/jlb.55.6.711.
8
IL-10 mediates susceptibility to Trypanosoma cruzi infection.白细胞介素-10介导对克氏锥虫感染的易感性。
J Immunol. 1994 Oct 1;153(7):3135-40.
9
Beneficial effects of interleukin-6 in neonatal mouse models of group B streptococcal disease.白细胞介素-6在B族链球菌病新生小鼠模型中的有益作用。
Infect Immun. 1994 Nov;62(11):4997-5002. doi: 10.1128/iai.62.11.4997-5002.1994.
10
High levels of interleukin-10 during the initial phase of fulminant meningococcal septic shock.暴发性脑膜炎球菌性败血症休克初始阶段白细胞介素-10水平升高。
J Infect Dis. 1995 Jan;171(1):229-32. doi: 10.1093/infdis/171.1.229.
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